{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:19:17Z","timestamp":1790705957360,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Post\u2010thrombotic syndrome (<jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content>) is the most common complication of deep vein thrombosis (<jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>). Current preventative strategies are limited to the daily wear of graduated compression stockings (<jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content>). The aim of this study was to evaluate early predictors of <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content>. One hundred and twenty\u2010two consecutive patients with a first <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> were prospectively recruited from diagnosis and followed for up to 6\u00a0months post\u2010end of anticoagulation. <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\u2010dimer was measured in 107 participants at presentation and <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>illalta scale was evaluated in 70 participants at a median of 2\u00a0weeks following diagnosis. <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> developed in 51\u00b76% of participants. <jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content> were obtained by 78\u00b71% of participants, with 33\u00b77% reporting daily wear at the end of follow\u2010up. Mean early <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>illalta scale was significantly higher in those with <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> (8\u00b71\u00a0\u00b1\u00a03\u00b77) compared to those without (2\u00b76\u00a0\u00b1\u00a02\u00b77, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001). Median <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\u2010dimer was significantly higher in those with <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> [3260\u00a0ng\/ml, interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>) 820\u20138000\u00a0ng\/ml] compared to those without (1540\u00a0ng\/ml, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 810\u20132520\u00a0ng\/ml, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001). The adjusted odds ratio for every one point increase in early <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>illalta scale was 1\u00b778 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 1\u00b719\u20132\u00b764; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005] and for <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\u2010dimer &gt;1910\u00a0ng\/ml it was 2\u00b771 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1\u00b705\u20137\u00b703; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704). These markers could enable targeted counselling regarding <jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content> for those at high risk of <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.12192","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T13:32:41Z","timestamp":1357565561000},"page":"817-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Presenting <scp>D<\/scp>\u2010dimer and early symptom severity are independent predictors for post\u2010thrombotic syndrome following a first deep vein thrombosis"],"prefix":"10.1111","volume":"160","author":[{"given":"Lara N.","family":"Roberts","sequence":"first","affiliation":[{"name":"King's Thrombosis Centre Department of Haematological Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj K.","family":"Patel","sequence":"additional","affiliation":[{"name":"King's Thrombosis Centre Department of Haematological Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paradzai B.","family":"Chitongo","sequence":"additional","affiliation":[{"name":"King's Thrombosis Centre Department of Haematological Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Bonner","sequence":"additional","affiliation":[{"name":"King's Thrombosis Centre Department of Haematological Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopen","family":"Arya","sequence":"additional","affiliation":[{"name":"King's Thrombosis Centre Department of Haematological Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/s-0037-1613447","article-title":"Body mass index is associated with the development of post\u2010thrombotic syndrome","volume":"89","author":"Ageno W.","year":"2003","journal-title":"Thrombosis & Haemostasis"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.10.025"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0309-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03953.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2299"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055289"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1175"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01333.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03339.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00098.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03002.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-10-200811180-00004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03294.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1160\/TH06-05-0258","article-title":"Review on the value of graduated compression stockings after deep vein thrombosis","volume":"96","author":"Kakkos S.K.","year":"2006","journal-title":"Thrombosis & Haemostasis"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2301"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04001.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.01.027"},{"key":"e_1_2_8_20_1","volume-title":"Venous Thromboembolic Diseases: the Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing","author":"National Clinical Guideline Centre","year":"2012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70195-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07601.x"},{"key":"e_1_2_8_23_1","first-page":"423","article-title":"The clinical course of deep\u2010vein thrombosis. 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