{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:06:11Z","timestamp":1791752771677,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This study aimed to determine the incidence\/prognostic impact of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                      53\n                    <\/jats:italic>\n                    mutation in 318 myelodysplastic syndrome (\n                    <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>\n                    ) patients, and to correlate the changes to cytogenetics, single nucleotide polymorphism array karyotyping and clinical outcome. The median age was 65\u00a0years (17\u201389\u00a0years) and median follow\u2010up was 45\u00a0months [95% confidence interval (\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ) 27\u201362\u00a0months].\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                      53\n                    <\/jats:italic>\n                    mutations occurred in 30 (9\u00b74%) patients, exclusively in isolated del5q (19%) and complex karyotype (\n                    <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>\n                    ) with \u20105\/5q\u2010(72%), correlated with International Prognostic Scoring System intermediate\u20102\/high,\n                    <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                    53 protein expression, higher blast count and leukaemic progression. Patients with mutant\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                      53\n                    <\/jats:italic>\n                    had a paucity of mutations in other genes implicated in myeloid malignancies. Median overall survival of patients with\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                      53\n                    <\/jats:italic>\n                    mutation was shorter than wild\u2010type (9\n                    <jats:italic>versus<\/jats:italic>\n                    66\u00a0months,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b7001) and it retained significance in multivariable model (Hazard Ratio 3\u00b78, 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    2\u00b73\u20136\u00b73,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b7001). None of the sequentially analysed samples showed a disappearance of the mutant clone or emergence of new clones, suggesting an early occurrence of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                      53\n                    <\/jats:italic>\n                    mutations. A reduction in mutant clone correlated with response to 5\u2010azacitidine, however clones increased in non\u2010responders and persisted at relapse. The adverse impact of\n                    <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                    53 persists after adjustment for cytogenetic risk and is of practical importance in evaluating prognosis. The relatively common occurrence of these mutations in two different prognostic spectrums of\n                    <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>\n                    , i.e. isolated 5q\u2010 and\n                    <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>\n                    with \u20105\/5q\u2010, possibly implies two different mechanistic roles for\n                    <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                    53 protein.\n                  <\/jats:p>","DOI":"10.1111\/bjh.12203","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T14:29:45Z","timestamp":1357741785000},"page":"660-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":227,"title":["<i>\n                      <scp>TP<\/scp>\n                      53\n                    <\/i>\n                    mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis"],"prefix":"10.1111","volume":"160","author":[{"given":"Austin G.","family":"Kulasekararaj","sequence":"first","affiliation":[{"name":"Department of Haematological Medicine King's College London School of Medicine London UK"},{"name":"Department of Haematology King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Haematology King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A.","family":"Mian","sequence":"additional","affiliation":[{"name":"Department of Haematological Medicine King's College London School of Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azim M.","family":"Mohamedali","sequence":"additional","affiliation":[{"name":"Department 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