{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:50:42Z","timestamp":1790419842758,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T00:00:00Z","timestamp":1358467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> mismatching is not considered a contraindication to allogeneic haematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Modern reduced\u2010intensity conditioning and reduced\u2010toxicity regimens cause much less myeloablation than conventional myeloablative regimens, such as cyclophosphamide with busulfan or total body irradiation, which may affect the incidence of pure red cell aplasia (<jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content>). We estimated the incidence and described the natural history of <jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content> in patients with major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010mismatched donor stem cells. Between 2007 and 2008, 161 (27% of all patients undergoing <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) underwent allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> with major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010mismatched stem cells and 12 (7\u00b75%) of these patients developed <jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content>. Thirty and ninety day <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell and myeloid cell chimerism and neutrophil and platelet engraftment did not differ between patients who developed <jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content> and those who did not. The only risk factor associated with <jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content> was the use of a fludarabine\/busulfan conditioning regimen. All patients with <jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content> needed red cell transfusion for several months after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> resulting in significant iron overload. Pure red cell aplasia resolved spontaneously in the majority (seven patients) but only resolved after stopping tacrolimus in three patients. Hence, after major <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010mismatched <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, the incidence of <jats:styled-content style=\"fixed-case\">PRCA<\/jats:styled-content> was 7\u00b75% and it resolved spontaneously or after withdrawal of immunosuppression in the majority of patients.<\/jats:p>","DOI":"10.1111\/bjh.12210","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T08:04:36Z","timestamp":1358496276000},"page":"798-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Incidence and natural history of pure red cell aplasia in major <scp>ABO<\/scp>\u2010mismatched haematopoietic cell transplantation"],"prefix":"10.1111","volume":"160","author":[{"given":"Fleur M.","family":"Aung","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The University of Texas MD 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