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Significant advances have been made in the diagnosis and treatment of <jats:styled-content style=\"fixed-case\">POEMS<\/jats:styled-content> syndrome over the last decade. Herein, the diagnostic criteria and characteristic features are reviewed, focusing the role of characteristic features in early diagnoses. Autologous peripheral blood stem cell transplantation has become the first\u2010line treatment for younger patients with normal organ function. Autologous transplantation has resulted in a high response rate and durable remission. Moreover, transplantation\u2010related morbidity and mortality has been significantly reduced over the past 5\u00a0years. Induction therapy before transplantation may improve the harvest of stem cells and decrease transplantation\u2010related morbidity. Melphalan and dexamethasone is an effective and well\u2010tolerated treatment for older patients or those with organ dysfunction. Novel agents may also offer benefits to patients with a poor performance status or renal dysfunction, and transform transplantation eligibility.<\/jats:p>","DOI":"10.1111\/bjh.12236","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T13:19:19Z","timestamp":1360329559000},"page":"303-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["New advances in the diagnosis and treatment of <scp>POEMS<\/scp> syndrome"],"prefix":"10.1111","volume":"161","author":[{"given":"Jian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Haematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao\u2010bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Haematology Peking Union Medical College Hospital, 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