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However, there is a subset of patients with a more guarded prognosis using this approach, who may benefit from haematopoietic allogeneic stem cell transplantation (allo<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Commonly used criteria for allo<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> in children, adolescents and young adults with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>1 include: induction failure, poor cytogenetics, persistent minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>), age, immunophenotype, white blood cell count at diagnosis and rapidity of induction response. Two\u2010year event\u2010free survival following allo<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>1 ranges from 50 to 80% depending on disease status, donor source, conditioning therapy, age and other risk factors. Future studies should focus on more precisely identifying poor\u2010risk features, such as disease genomics and host pharmacogenomics, refining <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> measurements, improving unrelated donor matching, reducing <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> prior to allo<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, and developing post\u2010allo<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> humoral and cellular therapy approaches.<\/jats:p>","DOI":"10.1111\/bjh.12239","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T12:47:37Z","timestamp":1360154857000},"page":"27-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Criteria for and outcomes of allogeneic haematopoietic stem cell transplant in children, adolescents and young adults with acute 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