{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:00:55Z","timestamp":1762506055709},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:00:00Z","timestamp":1360800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Until recently, both the British Society for Haematology and American College of Chest Physicians recommended platelet monitoring in all surgical patients receiving prophylactic low molecular weight heparin (<jats:styled-content style=\"fixed-case\">LMWH<\/jats:styled-content>) for the early diagnosis of heparin\u2010induced thrombocytopenia (<jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content>). These guidelines were reversed in 2012 based upon an analysis considering resource expenditure, assay result timeframes, and complications relating to <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> treatment. However, there are no large studies reviewing lower limb arthroplasty patients on an individual basis to determine the incidence of <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> in this patient group. This study investigated 10\u00a0797 patients who underwent primary hip or knee arthroplasty with <jats:styled-content style=\"fixed-case\">LMWH<\/jats:styled-content> prophylaxis over a 5\u00a0years period. 32\u00b76% of patients (<jats:italic>n\u00a0<\/jats:italic>=\u00a03515) had platelet counts recorded up to 14\u00a0d postoperatively with 13 patients (0\u00b737%) developing thrombocytopenia. Platelet counts recovered spontaneously in five patients, and two patients had other identifiable causes. Only one of the remaining six patients developed thrombosis indicating an incidence of <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content>\u2010related thrombosis of 0\u00b703%. The potential for identifying <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> with platelet monitoring in patients receiving <jats:styled-content style=\"fixed-case\">LMWH<\/jats:styled-content> prophylaxis is low and therefore routine monitoring for <jats:styled-content style=\"fixed-case\">HIT<\/jats:styled-content> is not justified.<\/jats:p>","DOI":"10.1111\/bjh.12242","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T09:56:54Z","timestamp":1360835814000},"page":"255-261","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Heparin\u2010induced thrombocytopenia following hip and knee arthroplasty"],"prefix":"10.1111","volume":"161","author":[{"given":"Johnathan D.","family":"Craik","sequence":"first","affiliation":[{"name":"The Elective Orthopaedic Centre Epsom General Hospital Epsom Surrey 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