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It is typified by the presence of lymphocyte predominant cells, which are <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>15<jats:sup>\u2212<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30<jats:sup>\u2212<\/jats:sup> and are found scattered amongst small <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010lymphocytes arranged in a nodular pattern. Patients typically are males presenting with localized, peripheral lymphadenopathy. Despite frequent and often late or multiple relapses the prognosis is favourable. Deaths due to <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> are uncommon, but secondary malignancies and other treatment toxicities contribute appreciably to overall mortality. Secondary aggressive non\u2010Hodgkin lymphoma can occur in approximately 7\u201314% of cases of <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>. Given this diseases' rarity, the optimal management is unclear and opinions differ as to whether treatment paradigms should be similar to or differ from those for classical Hodgkin lymphoma. This review provides an overview of the existing literature describing of the outcome and treatment approaches for limited and advanced stage <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.12244","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T13:17:30Z","timestamp":1360329450000},"page":"316-329","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Modern management of lymphocyte predominant <scp>H<\/scp>odgkin lymphoma"],"prefix":"10.1111","volume":"161","author":[{"given":"Katharine H.","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Medical Oncology British Columbia Cancer Agency Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry J.","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology British Columbia Cancer 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