{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:33:15Z","timestamp":1783625595746,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acute leukaemia in early childhood \u2010 and mainly infant leukaemia (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>) \u2013 is characterized by acquired genetic alterations, most commonly by the presence of distinct <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic> rearrangements (<jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic>\u2010r). The aim of this study was to investigate possible correlations between clinical features and molecular analyses of a series of 545 childhood leukaemia (\u226424\u00a0months of age) cases: 385 acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) and 160 acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>). The location of the genomic breakpoints was determined in a subset of 30 <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content>\u2010r<\/jats:italic> cases. The overall survival of the investigated cohort was 60\u00b75%, as determined by the Kaplan\u2010Meier method. Worse outcomes were associated with age at diagnosis \u22646\u00a0months (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001), high white blood cell count (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001), and <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic>\u2010r (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7002) in <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>, while children with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> displayed a poorer outcome (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7009) regardless of their age strata. Moreover, we present first evidence that <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic>\u2010r patients with poor outcome preferentially displayed chromosomal breakpoints within <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic> intron 11. Based on the literature, most <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic>\u2010r <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content> display a breakpoint localization towards intron 11, which in turn may explain their worse clinical course. In summary, the <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic> breakpoint localization is of clinical importance and should be considered as a novel outcome predictor for <jats:italic><jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content><\/jats:italic>\u2010r patients.<\/jats:p>","DOI":"10.1111\/bjh.12250","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T18:23:14Z","timestamp":1361470994000},"page":"224-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The distribution of <i><scp>MLL<\/scp><\/i> breakpoints correlates with outcome in infant acute leukaemia"],"prefix":"10.1111","volume":"161","author":[{"given":"Mariana","family":"Emerenciano","sequence":"first","affiliation":[{"name":"Paediatric Haematology\u2010Oncology Program Research Centre, Instituto Nacional de C\u00e2ncer Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Meyer","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biology\/ZAFES\/Diagnostic Centre of Acute Leukaemia (DCAL) Goethe\u2010University of Frankfurt Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela B.","family":"Mansur","sequence":"additional","affiliation":[{"name":"Paediatric Haematology\u2010Oncology Program Research Centre, Instituto Nacional de C\u00e2ncer Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Marschalek","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biology\/ZAFES\/Diagnostic Centre of Acute Leukaemia (DCAL) Goethe\u2010University of Frankfurt Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Pombo\u2010de\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Paediatric Haematology\u2010Oncology Program Research Centre, Instituto Nacional de C\u00e2ncer Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Brazilian Collaborative Study Group of Infant Acute Leukaemia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"2542","article-title":"Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion","volume":"61","author":"Alexander F. 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