{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:11:21Z","timestamp":1790172681438,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Primary peripheral\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010cell lymphoma, not otherwise specified (\n                    <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    ) of the thyroid is an extremely rare neoplasm. Six cases of primary\n                    <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    of the thyroid were analysed for clinicopathological features and genomic alteration patterns using oligo\u2010array comparative genomic hybridization. All patients had a diffusely enlarged thyroid and three cases showed leukaemic manifestation. Five of the six cases had anti\u2010thyroid antibodies and the remaining case showed hypothyroidism, suggesting that all cases had autoimmune thyroiditis. Except for one early relapsed case, the remaining five patients are alive and three of these five individuals have survived for 70\u00a0months or more. Interestingly, two cases showed spontaneous regressions after partial thyroid biopsy without any therapy. Leukaemic manifestation disappeared after irradiation of the thyroid mass in another two cases. The tumour cells were positive for\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    3,\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 and\n                    <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>\n                    3 in all cases, suggesting that the tumour cells are of a type 1 helper\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010cell origin. All six cases showed genomic alterations that were different from those previously reported for\n                    <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    . The loss of 6q24\u00b72 was characteristic and was detected in four of the six cases. These results suggest that primary\n                    <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    of the thyroid arising from autoimmune thyroiditis is a distinct disease entity among heterogeneous\n                    <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/bjh.12255","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T12:49:34Z","timestamp":1361450974000},"page":"214-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Primary peripheral\n                    <scp>T<\/scp>\n                    \u2010cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis"],"prefix":"10.1111","volume":"161","author":[{"given":"Noriaki","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Centre Research Institute Nagoya Japan"},{"name":"Department of Cancer Genetics Nagoya University Graduate School of Medicine at Aichi Cancer Centre Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Nishikori","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Izumi","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Pathology Tochigi Cancer Centre Utsunomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Haematology and Molecular Medicine Unit Nagasaki University Graduate School of Biomedical Sciences Atomic Bomb Disease Institute Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Sawayama","sequence":"additional","affiliation":[{"name":"Haematology and Molecular Medicine Unit Nagasaki University Graduate School of Biomedical Sciences Atomic Bomb Disease Institute Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Niino","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Tashima","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Pathology Tochigi Cancer Centre Utsunomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Multi\u2010institutional Clinical Trial Support Centre National Cancer Centre Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Seto","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Centre Research Institute Nagoya Japan"},{"name":"Department of Cancer Genetics Nagoya University Graduate School of Medicine at Aichi Cancer Centre Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Tsukasaki","sequence":"additional","affiliation":[{"name":"Haematology and Molecular Medicine Unit Nagasaki University Graduate School of Biomedical Sciences Atomic Bomb Disease Institute Nagasaki Japan"},{"name":"Department of Haematology National Cancer Centre Hospital East Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.d01-515.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-074468"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199903)21:2<160::AID-HED10>3.0.CO;2-F"},{"key":"e_1_2_7_5_1","first-page":"946","article-title":"CD30 positive (non\u2010anaplastic) peripheral T\u2010cell lymphoma of the thyroid gland","volume":"84","author":"Forconi F.","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/582364"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3080"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1210\/jcem.86.10.7953","article-title":"Thyrocytes from autoimmune thyroid disorders produce the chemokines IP\u201010 and Mig and attract CXCR3\u00a0+\u00a0 lymphocytes","volume":"86","author":"Garcia\u2010Lopez M.A.","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.09.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3283330848"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.158"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/10507250050137824"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07956.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402458"},{"key":"e_1_2_7_15_1","first-page":"214","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Isaacson P.G.","year":"2009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-346890"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10351"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804295105"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210432"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12030"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1808"},{"key":"e_1_2_7_22_1","first-page":"306","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Pileri S.A.","year":"2009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.15.3576"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091277"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345149"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.035253"},{"key":"e_1_2_7_27_1","first-page":"1401","article-title":"Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation","volume":"7","author":"Seto M.","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0542"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1352"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-327791"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-310342"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705083361915"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12255","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:41:30Z","timestamp":1698655290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,21]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/bjh.12255"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12255","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,21]]},"assertion":[{"value":"2012-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}