{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:48:45Z","timestamp":1791125325981,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study prospectively compared the effect of secondary prophylaxis to episodic treatment on target joint (<jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>) range of motion (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>), number of joint haemorrhages and new <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> development in patients with moderate or severe haemophilia. Two\u2010hundred and eighty\u2010six males, 17% in prophylaxis, 83% in episodic treatment group, participating in the Centers for Disease Control and Prevention's Universal Data Collection project, fulfilled inclusion criteria: age &gt;2\u00a0years at enrolment, free of <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>s at enrolment, developed at least one <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> after enrolment, and received either prophylaxis or episodic treatment continuously for two follow\u2010up visits after <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> development. The outcomes of interest \u2013 percentage change in <jats:styled-content style=\"fixed-case\">TJ ROM<\/jats:styled-content>, number of joint haemorrhages and new <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> development, were modelled using multivariate linear, Poisson and logistic regression techniques respectively. Individuals who received secondary prophylaxis in comparison to episodic treatment were younger at <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> development (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701); there was no difference in the decrease in <jats:styled-content style=\"fixed-case\">TJ ROM<\/jats:styled-content> between the two groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b79). Factors significantly associated with a higher rate of haemarthroses included episodic treatment, severe haemophilia, age &gt;5\u00a0years at <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> development, obesity and inhibitor negative status. Secondary prophylaxis significantly decreased haemarthroses but was not associated with a significant improvement in <jats:styled-content style=\"fixed-case\">TJ ROM<\/jats:styled-content> or with new <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> development.<\/jats:p>","DOI":"10.1111\/bjh.12267","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T05:53:54Z","timestamp":1361512434000},"page":"424-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The effect of secondary prophylaxis <i>versus<\/i> episodic treatment on the range of motion of target joints in patients with haemophilia"],"prefix":"10.1111","volume":"161","author":[{"given":"Sweta","family":"Gupta","sequence":"first","affiliation":[{"name":"Indiana Hemophilia and Thrombosis Center Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azfar\u2010E\u2010Alam","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Soucie","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Manco\u2010Johnson","sequence":"additional","affiliation":[{"name":"University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Michigan State University East Lansing MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Lane","sequence":"additional","affiliation":[{"name":"Intermountain Hemophilia and Thrombosis Center, Primary Children's Medical Center Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robina","family":"Ingram\u2010Rich","sequence":"additional","affiliation":[{"name":"Oregon Hemophilia Center, CDRC\/Doernbecher Children's Hospital, Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan C.","family":"Gill","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin and the Comprehensive Centre for Bleeding Disorders, Blood Center of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Joint Outcomes Committee of Universal Data Collection and the Hemophilia Treatment Centres Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6161.469"},{"key":"e_1_2_8_3_1","first-page":"691","article-title":"Modern treatment of haemophilia","volume":"73","author":"Berntorp E.","year":"1995","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01810.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.9.s1.12.x"},{"key":"e_1_2_8_6_1","first-page":"1152","article-title":"Blood safety monitoring among persons with bleeding disorders \u2013 United States, May 1998\u2010June 2002","volume":"51","author":"Centers for Disease Control and Prevention (CDC)","year":"2002","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_8_7_1","first-page":"534","article-title":"Effects of secondary prophylaxis in hemophilia children with frequent hemarthrosis (Abstract)","volume":"37","author":"Cohen A.","year":"1997","journal-title":"Transfusion"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03650.x"},{"key":"e_1_2_8_9_1","first-page":"535","article-title":"Factors affecting use of prophylaxis in hemophilia. 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