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Although most people are either D+ or D\u2212, there is a plethora of D variants, often categorized as either weak D or partial D. These two types are inadequately defined and the dichotomy is potentially misleading. <jats:styled-content style=\"fixed-case\">DVI<\/jats:styled-content> is the D variant most commonly associated with anti\u2010D production and <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> guidelines recommend that patients are tested with anti\u2010D reagents that do not react with <jats:styled-content style=\"fixed-case\">DVI<\/jats:styled-content>. Weak D types 1, 2, and 3 are seldom, if ever, associated with alloanti\u2010D production, so a policy recommendation would be to treat patients with those D variants as D+, to preserve D\u2212 stocks, whereas patients with all other D variants would be treated as D\u2212. 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