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An acquired mutation <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic><jats:sup>V617F<\/jats:sup> can be found in all three disorders and shows many of the phenotypic abnormalities of the diseases in murine models. The disease phenotype is also influenced by other unknown genetic or epigenetic factors. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) are 18\u201324 nucleotide single\u2010stranded non\u2010protein\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that function primarily as gene repressors by binding to their target messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s. There is growing evidence that mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s regulate haematopoiesis in both haematopoietic stem cells and committed progenitor cells. Here, we review the field of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> biology and its regulatory roles in normal haematopoiesis with an emphasis on mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> deregulations in <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>s. Continued research into how mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s impact <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic><jats:sup>V617F<\/jats:sup> clonal expansion, differential haematopoiesis among different <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>s, disease progression and leukaemia transformation will lead to a better understanding of the development of these disorders, their clinical manifestations, and their treatment.<\/jats:p>","DOI":"10.1111\/bjh.12276","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T09:15:30Z","timestamp":1361783730000},"page":"471-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Micro<scp>RNA<\/scp>s in myeloproliferative neoplasms"],"prefix":"10.1111","volume":"161","author":[{"given":"Huichun","family":"Zhan","sequence":"first","affiliation":[{"name":"James J. 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