{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:05:47Z","timestamp":1773374747895,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Adolescents aged 15\u201318\u00a0years with acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) have been historically reported to have a poorer prognosis than younger children. We retrospectively analysed the characteristics and outcome of 67 adolescents included in a population\u2010based series of 1125 non\u2010infant cases that were enrolled into four Austrian <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BFM<\/jats:styled-content> (Berlin\u2010Frankfurt\u2010M\u00fcnster) multicentre trials at paediatric institutions within a 25\u2010year period. Five\u2010year event\u2010free survival (<jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) were 66\u00a0\u00b1\u00a06% and 76\u00a0\u00b1\u00a05% respectively, and thus lower than in younger children (83\u00a0\u00b1\u00a01%, 91\u00a0\u00b1\u00a01%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). This was not due to an increased cumulative incidence of relapse (CIR) (5\u2010year CIR: 19\u00a0\u00b1\u00a05% vs. 13\u00a0\u00b1\u00a01%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7284), but due to an increased incidence of treatment\u2010related death [5\u2010year cumulative incidence of death (<jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content>): 15\u00a0\u00b1\u00a04% vs. 3\u00a0\u00b1\u00a00%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001] as a first event. Furthermore, while 44\/67 (66%) non\u2010high\u2010risk adolescents had favourable 5\u2010year <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates (76\u00a0\u00b1\u00a07%, 89\u00a0\u00b1\u00a05%), 18\/67 (27%) high\u2010risk adolescents had an inferior outcome (5\u2010year <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>: 56\u00a0\u00b1\u00a012%, <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> 61\u00a0\u00b1\u00a011%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Among the latter patients the <jats:styled-content style=\"fixed-case\">CID<\/jats:styled-content> was significantly higher than in younger high\u2010risk children (22\u00a0\u00b1\u00a010% vs. 6\u00a0\u00b1\u00a02%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7020). Given that adolescent age is an independent risk factor for death as a first event, this specific age group may need particular vigilance when receiving intense <jats:styled-content style=\"fixed-case\">BFM<\/jats:styled-content>\u2010type chemotherapy, as relapse\u2010free survival is similar to younger children.<\/jats:p>","DOI":"10.1111\/bjh.12292","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T02:38:46Z","timestamp":1363142326000},"page":"556-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The inferior prognosis of adolescents with acute lymphoblastic leukaemia (<scp>ALL<\/scp>) is caused by a higher rate of treatment\u2010related mortality and not an increased relapse rate \u2013 a population\u2010based analysis of 25\u00a0years of the <scp>A<\/scp>ustrian <scp>ALL\u2010BFM<\/scp> (Berlin\u2010Frankfurt\u2010M\u00fcnster) Study Group"],"prefix":"10.1111","volume":"161","author":[{"given":"Herbert","family":"Pichler","sequence":"first","affiliation":[{"name":"Paediatric Haematology and Oncology St Anna Children's Hospital Department of Paediatrics Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Reism\u00fcller","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology St Anna Children's Hospital Department of Paediatrics Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"Dworzak","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology St Anna Children's Hospital Department of Paediatrics Medical University of Vienna  Vienna Austria"},{"name":"Children's Cancer Research Institute (CCRI) St. Anna Kinderkrebsforschung  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"P\u00f6tschger","sequence":"additional","affiliation":[{"name":"Children's Cancer Research Institute (CCRI) St. Anna Kinderkrebsforschung  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Urban","sequence":"additional","affiliation":[{"name":"Division of Paediatric Haematology and Oncology Department of Paediatric and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Meister","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Landeskinderklinik Linz  Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Panzer\u2010Gr\u00fcmayer","sequence":"additional","affiliation":[{"name":"Children's Cancer Research Institute (CCRI) St. Anna Kinderkrebsforschung  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar A.","family":"Haas","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology St Anna Children's Hospital Department of Paediatrics Medical University of Vienna  Vienna Austria"},{"name":"Children's Cancer Research Institute (CCRI) St. Anna Kinderkrebsforschung  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andishe","family":"Attarbaschi","sequence":"additional","affiliation":[{"name":"Paediatric 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