{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:08:10Z","timestamp":1778778490732,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The use of allogeneic haematopoietic stem cell transplantation (Allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) is a standard treatment option for many patients with haematological malignancies. Historically, patients requiring intensive care unit (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>) admission for transplant\u2010related toxicities have fared extremely poorly, with high <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> mortality rates. Little is known about the impact of reduced intensity Allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> conditioning regimens in older patients on the <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> and subsequent long\u2010term outcomes. A retrospective analysis of data collected from 164 consecutive Allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients admitted to <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> for a total of 213 admissions, at a single centre over an 11\u00b75\u2010year study period was performed. Follow\u2010up was recorded until 31 <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2011. Autologous <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients were excluded. In this study we report favourable <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> survival following Allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> and, for the first time, demonstrate significantly better survival for patients who underwent Allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> with reduced intensity conditioning compared to those treated with myeloablative conditioning regimens. In addition, we identified the need for ventilation (invasive or non\u2010invasive) as an independently significant adverse factor affecting short\u2010term <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> outcome. For patients surviving <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admission, subsequent long\u2010term overall survival was excellent; 61% and 51% at 1 and 5\u00a0years, respectively. Reduced intensity Allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> patients admitted to <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> with critical illness have improved survival compared to myeloablative Allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients.<\/jats:p>","DOI":"10.1111\/bjh.12294","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T09:15:41Z","timestamp":1363598141000},"page":"578-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning"],"prefix":"10.1111","volume":"161","author":[{"given":"William M.","family":"Townsend","sequence":"first","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailsa","family":"Holroyd","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Pearce","sequence":"additional","affiliation":[{"name":"British Society for Blood and Marrow Transplantation London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Mackinnon","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Free London NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakesh","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine University College London Hospitals NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony H.","family":"Goldstone","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Linch","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl S.","family":"Peggs","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsty J.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervyn","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine University College London Hospitals NHS Foundation Trust and UCL Medical School London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C. 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