{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:09:06Z","timestamp":1783105746418,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Summary<\/jats:title>Previous studies have shown that patients diagnosed with some autoimmune (AI<\/jats:styled-content>) diseases are at an increased risk of leukaemia but limited data are available on survival. We systematically analysed the risks (standardized incidence ratio, SIR<\/jats:styled-content>) and survival (hazard ratio, HR<\/jats:styled-content>) in nine types of leukaemia among 402\u00a0462 patients hospitalized for any of 33 AI<\/jats:styled-content> diseases and compared to persons not hospitalized for AI<\/jats:styled-content> diseases. Risk for all leukaemia was increased after 13 AI<\/jats:styled-content> diseases and survival was decreased after six AI<\/jats:styled-content> diseases. SIR<\/jats:styled-content>s were increased after all AI<\/jats:styled-content> diseases for seven types of leukaemia, including SIR<\/jats:styled-content> 1\u00b769 (95% confidence interval (CI<\/jats:styled-content>): 1\u00b729\u20132\u00b719) for acute lymphoblastic leukaemia (ALL<\/jats:styled-content>), 1\u00b785 (95% CI<\/jats:styled-content>: 1\u00b765\u20132\u00b707) for acute myeloid leukaemia, 1\u00b768 (95% CI<\/jats:styled-content>: 1\u00b737\u20132\u00b704) for chronic myeloid leukaemia, 2\u00b720 (95% CI<\/jats:styled-content>: 1\u00b769\u20132\u00b781) for \u2018other myeloid leukaemia\u2019, 2\u00b745 (95% 1\u00b799\u20132\u00b798) for \u2018other and unspecified leukaemia\u2019, 1\u00b781 (95% CI<\/jats:styled-content>: 1\u00b711\u20132\u00b781) for monocytic leukaemia, and 1\u00b736 (95% CI<\/jats:styled-content>: 1\u00b708\u20131\u00b769) for myelofibrosis. The HR<\/jats:styled-content>s were increased for four types of leukaemia, most for myelofibrosis (1\u00b774, 95% CI<\/jats:styled-content>: 1\u00b733\u20132\u00b729) and ALL<\/jats:styled-content> (1\u00b742, 95% CI<\/jats:styled-content>: 1\u00b703\u20131\u00b795). Some AI<\/jats:styled-content> diseases, including rheumatoid arthritis, were associated with increased SIR<\/jats:styled-content>s and HR<\/jats:styled-content>s in many types of leukaemia. The present data showed increases in risk and decreases in survival for many types of leukaemia after various AI<\/jats:styled-content> diseases. Leukaemia is a rare complication in AI<\/jats:styled-content> disease but findings about this comorbidity at the time of leukaemia diagnosis may help to optimize the treatment and improve survival.<\/jats:p>","DOI":"10.1111\/bjh.12330","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T10:16:21Z","timestamp":1365502581000},"page":"677-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Subsequent leukaemia in autoimmune disease patients"],"prefix":"10.1111","volume":"161","author":[{"given":"Kari","family":"Hemminki","sequence":"first","affiliation":[{"name":"Division of Molecular Genetic Epidemiology German Cancer Research Centre (DKFZ) Heidelberg Germany"},{"name":"Centre for Primary Health Care Research Lund University Malm\u00f6 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Care Research Lund University Malm\u00f6 Sweden"},{"name":"Stanford Prevention Research Center Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Centre for Primary Health Care Research Lund University Malm\u00f6 Sweden"},{"name":"Stanford Prevention Research Center Stanford University School of Medicine Stanford CA 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