{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:09:31Z","timestamp":1792292971373,"version":"4.4.0"},"reference-count":124,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Gaucher disease is an autosomal, recessively inherited, lysosomal storage disease, which has been associated with gammopathies and malignancies. This report represents the results of a systematic review of the literature on the prevalence of monoclonal gammopathies and malignancies in Gaucher disease. A <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed search identified 365 studies, of which 80 reported on concomitant <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>aucher disease and malignancies and\/or gammopathies (15 cohort\/cross sectional studies, and 65 case reports\/series). Based on these studies, we conclude that compared to the general population, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>aucher patients have an increased risk of cancer in general [pooled relative risk of 1\u00b770 (95% confidence interval 1\u00b727\u20132\u00b731)], and multiple myeloma and haematological malignancies in particular (estimated risk between 25\u00b70 and 51\u00b71 and 3\u00b75 and 12\u00b77, respectively). In addition, an increased risk has been reported for hepatocellular carcinoma and renal cell carcinoma. Several factors have been hypothesized to play a role in the pathophysiology. These include: splenectomy, immune dysregulation, endoplasmic reticulum stress, genetic modifiers, altered iron metabolism and insulin resistance.<\/jats:p>","DOI":"10.1111\/bjh.12335","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T08:33:23Z","timestamp":1366274003000},"page":"832-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Malignancies and monoclonal gammopathy in <scp>G<\/scp>aucher disease; a systematic review of the literature"],"prefix":"10.1111","volume":"161","author":[{"given":"Maarten","family":"Arends","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Centre University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"van Dussen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Centre University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Biegstraaten","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Centre University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla E. M.","family":"Hollak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Centre University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,18]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"129","article-title":"Gaucher's disease associated with monoclonal gammapathy of undetermined significance: a case report","volume":"78","author":"Airo R.","year":"1993","journal-title":"Haematologica"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.1.19"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196648040-00003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05503.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105233242104"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1979.tb00419.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.5858\/2003-127-e242-SLAIAP","article-title":"Splenic lymphoma arising in a patient with Gaucher disease. A case report and review of the literature","volume":"127","author":"Bertram H.C.","year":"2003","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03270500081038"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010201)91:3<457::AID-CNCR1022>3.0.CO;2-J"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1612"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/BG5VA8JRDQH1M7HN"},{"key":"e_1_2_7_14_1","first-page":"1108","article-title":"Multiple myeloma arising from monoclonal gammopathy of undetermined significance in a patient with Gaucher's disease","volume":"121","author":"Brady K.","year":"1997","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2003.10.007"},{"key":"e_1_2_7_16_1","first-page":"129","article-title":"Coincidence of Gaucher disease with primary hepatocellular carcinoma","volume":"126","author":"Breiden\u2010Langen C.M.","year":"1991","journal-title":"Leber, Magen, Darm"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-006-0176-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90313-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1985.tb02269.x"},{"key":"e_1_2_7_20_1","first-page":"149","article-title":"Abnormalities of cellular immunity and natural killer cells in Gaucher's disease","volume":"23","author":"Burstein Y.","year":"1987","journal-title":"Journal of Clinical & Laboratory Immunology"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.09.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21278"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20579"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196709000-00005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711160403"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6243"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/65.1.103"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.63.744.899"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025902113005"},{"key":"e_1_2_7_30_1","first-page":"673","article-title":"Gaucher's disease associated with a cerebral astrocytoma. A case report involving an adult","volume":"12","author":"Davis M.","year":"1961","journal-title":"American Practitioner and Digest of Treatment"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0477-2"},{"key":"e_1_2_7_32_1","first-page":"479","article-title":"Enzyme replacement therapy decreases hypergammaglobulinemia in Gaucher's disease","volume":"83","author":"Deibener J.","year":"1998","journal-title":"Haematologica"},{"key":"e_1_2_7_33_1","first-page":"460","article-title":"Amyloidosis. An unusual complication of Gaucher's disease","volume":"102","author":"Dikman S.H.","year":"1978","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506121003619351"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200309000-00009"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008306414822"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90363-I"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.08.004"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0441-8"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840715)54:2<312::AID-CNCR2820540222>3.0.CO;2-I"},{"key":"e_1_2_7_41_1","first-page":"63","article-title":"Sequential appearance of breast carcinoma, multiple myeloma and Gaucher's disease","volume":"73","author":"Gal R.","year":"1988","journal-title":"Haematologica"},{"key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1001\/archinte.1982.00340250195035","article-title":"Coexistence of Gaucher's disease and multiple myeloma","volume":"142","author":"Garfinkel D.","year":"1982","journal-title":"Archives of Internal Medicine"},{"key":"e_1_2_7_43_1","first-page":"278","article-title":"Gaucher's disease and acute leukemia","volume":"28","author":"Gelfand M.I.","year":"1961","journal-title":"Journal of the Mount Sinai Hospital, New York"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090399"},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/ajcp\/20.10.963","article-title":"Electrophoretic studies in Gaucher's disease","volume":"20","author":"Goldfarb A.","year":"1950","journal-title":"American Journal of Clinical Pathology"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(88)80559-2"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/asheducation.V2012.1.13.3797921","article-title":"Gaucher disease and other storage disorders","volume":"2012","author":"Grabowski G.A.","year":"2012","journal-title":"Hematology\/the Education Program of the American Society of Hematology"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-1-199501010-00005"},{"key":"e_1_2_7_49_1","first-page":"1","volume-title":"The Online Metabolic and Molecular Bases of Inherited Disease","author":"Grabowski G.A.","year":"2010"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-387324"},{"key":"e_1_2_7_51_1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1182\/blood.V3.11.1221.1221","article-title":"Adult Gaucher's disease, with special reference to the variations in its clinical course and the value of sternal puncture as an aid to its diagnosis","volume":"3","author":"Groen J.","year":"1948","journal-title":"Blood"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2009.04.002"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-5-639"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109057948"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000202"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1258\/smj.2011.011178"},{"key":"e_1_2_7_57_1","unstructured":"Higgins J.&Green S.(2011)Cochrane handbook for systematic reviews of interventionsVersion 5.1.0. 1\u20103\u20102011."},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.1997.0137"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00198347"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.07.010"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.07.015"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00607.x"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1148\/115.1.85"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1986.tb00119.x"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.78B5.0780702"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830215)51:4<712::AID-CNCR2820510426>3.0.CO;2-6"},{"key":"e_1_2_7_67_1","first-page":"33","article-title":"Phenotypic manifestations of Gaucher disease: clinical features in 48 biochemically verified type 1 patients and comment on type 2 patients","volume":"95","author":"Kolodny E.H.","year":"1982","journal-title":"Progress in Clinical and Biological Research"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1979.tb02681.x"},{"key":"e_1_2_7_69_1","first-page":"ECR02","article-title":"Multidrug resistance and myelomonocytic leukaemia in gaucher's disease","volume":"88","author":"Krishnan B.","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa01133202"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1189"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1702"},{"key":"e_1_2_7_73_1","first-page":"177","article-title":"The pathology of Gaucher disease","volume":"95","author":"Lee R.E.","year":"1982","journal-title":"Progress in Clinical and Biological Research"},{"key":"e_1_2_7_74_1","first-page":"481","article-title":"A study of acid beta\u2010glucosidase in a patient with Gaucher disease and leukemia","volume":"95","author":"Leibovitz\u2010BenGershon Z.","year":"1982","journal-title":"Progress in Clinical and Biological Research"},{"key":"e_1_2_7_75_1","first-page":"3937","article-title":"Enzyme replacement therapy for Gaucher's disease in patient treated for non\u2010small cell lung cancer","volume":"28","author":"Leone J.P.","year":"2008","journal-title":"Anticancer Research"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.09.002"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199106000-00007"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200941109"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21684"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-386862"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198201000-00005"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.28.9.757-d"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21492"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02725.x"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1982.tb02120.x"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198203000-00030"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199304000-00022"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830290403"},{"key":"e_1_2_7_89_1","first-page":"413","article-title":"[Uncommon combination of multiple myeloma in three patients]","volume":"46","author":"Mateja F.","year":"2000","journal-title":"Vnitrn\u00ed L\u00e9karstv\u00ed"},{"key":"e_1_2_7_90_1","first-page":"122","article-title":"Multiple Myeloma Complicating Gaucher's Disease","volume":"136","author":"Miller W.","year":"1982","journal-title":"The Western Journal of Medicine"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003308107"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6381.1864"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2004.07.009"},{"key":"e_1_2_7_94_1","first-page":"91","article-title":"Richter's transformation of lymphoma complicating Gaucher's disease","volume":"3","author":"Paulson J.A.","year":"1989","journal-title":"Hematologic Pathology"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809057621"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199809)59:1<87::AID-AJH17>3.0.CO;2-Z"},{"key":"e_1_2_7_97_1","first-page":"537","article-title":"Coincidence of multiple myeloma with Gaucher's disease","volume":"1","author":"Pinkhas J.","year":"1965","journal-title":"Israel Journal of Medical Sciences"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199505000-00015"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V31.5.633.633"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21839"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi240"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4672"},{"key":"e_1_2_7_103_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1001\/archinte.1980.00330190127042","article-title":"Coexistence of IgA myeloma and Gaucher's disease","volume":"140","author":"Ruestow P.C.","year":"1980","journal-title":"Archives of Internal Medicine"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.141"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910410507"},{"key":"e_1_2_7_106_1","first-page":"376","article-title":"Association of Hodgkin disease and Gaucher disease","volume":"98","author":"Sharer L.R.","year":"1974","journal-title":"Archives of Pathology"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830120212"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930701)72:1<219::AID-CNCR2820720139>3.0.CO;2-Y"},{"key":"e_1_2_7_109_1","first-page":"388","article-title":"Gaucher's disease: a disease with chronic stimulation of the immune system","volume":"106","author":"Shoenfeld Y.","year":"1982","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509054770"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0610-2"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810203191603"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.263"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21362"},{"key":"e_1_2_7_115_1","first-page":"56","article-title":"Coexistence of bronchogenic carcinoma and Gaucher disease","volume":"101","author":"Tsung S.H.","year":"1977","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1975.tb04961.x"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1291"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.09.007"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.11.172"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31806451d3"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-871201"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91038-7"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.03.004"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21369"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0643-4"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12335","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T04:34:59Z","timestamp":1698640499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,18]]},"references-count":124,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/bjh.12335"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12335","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,18]]},"assertion":[{"value":"2013-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}