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Patients who never had a cardiac <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2* measurement were &lt;18\u00a0years, had iron intake \u22640\u00b74\u00a0mg\/kg per day, or a serum ferritin &lt;2500\u00a0ng\/ml. A history of normal <jats:styled-content style=\"fixed-case\">CMR T<\/jats:styled-content>2* was the main risk factor for a delay in subsequent assessment of &gt;2\u00a0years. Deferoxamine (22\u00b78%) was more commonly used in patients with Hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> Virus or high serum creatinine. Deferiprone (20\u00b76%) was less commonly prescribed in patients with elevated alanine aminotransferase; while a deferoxamine\u00a0+\u00a0deferiprone combination (17\u00b79%) was more commonly used in patients with serum ferritin &gt;2500\u00a0ng\/ml or <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content> T2* &lt;20\u00a0ms. Deferasirox (38\u00b73%) was more commonly prescribed in patients &lt;18\u00a0years, but less commonly used in those with heart disease or high iron intake. These observations largely echoed guidelines at the time, although some practices are expected to change in light of evolving evidence.<\/jats:p>","DOI":"10.1111\/bjh.12340","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T16:01:49Z","timestamp":1366300909000},"page":"872-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Assessment and management of iron overload in \u03b2\u2010thalassaemia major patients during the 21st century: a real\u2010life experience from the <scp>I<\/scp>talian <scp>W<\/scp>ebthal project"],"prefix":"10.1111","volume":"161","author":[{"given":"Antonio","family":"Piga","sequence":"first","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled M.","family":"Musallam","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties IRCCS Ca\u2019 Granda Foundation Maggiore Policlinico Hospital University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Domenica","family":"Cappellini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties IRCCS Ca\u2019 Granda Foundation Maggiore Policlinico Hospital University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca","family":"Forni","sequence":"additional","affiliation":[{"name":"Centro della Microcitemia e Anemie Congenite Ospedale Galliera Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Quarta","sequence":"additional","affiliation":[{"name":"Haematology Unit \u201cDi Summa\u201d Hospital Brindisi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Chiavilli","sequence":"additional","affiliation":[{"name":"Servizio di Immunoematologia e Trasfusione S.I.T. 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