{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:16:54Z","timestamp":1760242614005},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Most cases of human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>)\u2010associated non\u2010<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>odgkin <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ymphoma (<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>) are of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell origin; T\u2010cell <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>s are rarely reported. Within a single centre prospective cohort of 370 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>, 17 (5%) were of T\u2010cell origin (82% male; median age, 39\u00a0years). Median <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ cell count was 0\u00b7194\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l and 41% had undetectable plasma <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> at lymphoma diagnosis. All patients received combination antiretroviral therapy during chemotherapy. All histological samples were centrally reviewed. The distribution of the histological subtypes differed from the general population with absence of angioimmunoblastic subtype. Lymphoma was disseminated in 14 patients, and seven patients had performance status &gt;2. All patients received full\u2010dose chemotherapy: eight standard and nine intensive regimens. Two patients who received intensive chemotherapy died during therapy. The complete remission rate was 53%; 62\u00b75% with standard therapy and 44% with intensive therapy. After a median follow\u2010up of 7\u00b72\u00a0years, the median overall survival was 9\u00b74\u00a0months. Most deaths (85%) occurred within the first year following diagnosis, as a consequence of lymphoma progression in 10\/13 cases. In this rare but severe complication of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection the use of intensive chemotherapy does not appear to be beneficial for response, with increased toxicity.<\/jats:p>","DOI":"10.1111\/bjh.12341","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T08:33:15Z","timestamp":1366273995000},"page":"843-851","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peripheral <scp>T<\/scp>\u2010cell lymphoma in <scp>HIV<\/scp>\u2010infected patients: a study of 17 cases in the combination antiretroviral therapy era"],"prefix":"10.1111","volume":"161","author":[{"given":"Laurent","family":"Gilardin","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Immunologie Clinique H\u00f4pital Saint\u2010Louis AP\u2010HP Paris 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