{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:34:59Z","timestamp":1781822099787,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>B\u2010cell lymphoma, unclassifiable (B\u2010<jats:styled-content style=\"fixed-case\">UCL<\/jats:styled-content>), with features intermediate between diffuse large B\u2010cell lymphoma and Burkitt lymphoma, is a poorly characterized entity. Therefore, we investigated cases of B\u2010<jats:styled-content style=\"fixed-case\">UCL<\/jats:styled-content> treated by the Nebraska Lymphoma Study Group (<jats:styled-content style=\"fixed-case\">NLSG<\/jats:styled-content>). We searched the <jats:styled-content style=\"fixed-case\">NLSG<\/jats:styled-content> registry for years 1985\u20132010 for cases of B\u2010<jats:styled-content style=\"fixed-case\">UCL<\/jats:styled-content>. Immunohistochemical stains and fluorescence <jats:italic>in situ<\/jats:italic> hybridization studies for <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BCL<\/jats:styled-content>2<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>6<\/jats:italic> gene rearrangements were performed. Among the 39 cases studied, 54% were male and 46% were female, with a median age of 69\u00a0years. The majority of patients presented with advanced\u2010stage disease (62%) and had high (3\u20135) International Prognostic Index (<jats:styled-content style=\"fixed-case\">IPI<\/jats:styled-content>) scores (54%). The median overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was only 9\u00a0months and the 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was 30%. Patients with low <jats:styled-content style=\"fixed-case\">IPI<\/jats:styled-content> scores (0\u20132) had a better survival than those with high scores (3\u20135). The cases were genetically heterogeneous and included 11 \u2018double\u2010hit\u2019 lymphomas with rearrangements of both <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2<\/jats:italic> or <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>6<\/jats:italic>. None of the immunohistochemical or genetic features was predictive of survival. This B\u2010cell lymphoma is a morphologically\u2010recognizable entity with a spectrum of genetic abnormalities. New and better treatments are needed for this aggressive lymphoma.<\/jats:p>","DOI":"10.1111\/bjh.12343","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T16:01:35Z","timestamp":1366300895000},"page":"40-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["<scp>B<\/scp>\u2010cell lymphoma, unclassifiable, with features intermediate between diffuse large <scp>B<\/scp>\u2010cell lymphoma and burkitt lymphoma: study of 39 cases"],"prefix":"10.1111","volume":"162","author":[{"given":"Anamarija M.","family":"Perry","sequence":"first","affiliation":[{"name":"Department of Pathology University of Manitoba Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Crockett","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavana J.","family":"Dave","sequence":"additional","affiliation":[{"name":"Human Genetics Laboratory Munroe\u2010Meyer Institute University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Althof","sequence":"additional","affiliation":[{"name":"Human Genetics Laboratory Munroe\u2010Meyer Institute University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Winkler","sequence":"additional","affiliation":[{"name":"Human Genetics Laboratory Munroe\u2010Meyer Institute University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Aoun","sequence":"additional","affiliation":[{"name":"Department of Pathology City of Hope National Medical Center Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Greiner","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Bierman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gregory Bociek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Vose","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"Armitage","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis D.","family":"Weisenburger","sequence":"additional","affiliation":[{"name":"Department of Pathology City of Hope National Medical Center Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-297879"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.10.027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0113"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08947.x"},{"key":"e_1_2_6_6_1","first-page":"321","volume-title":"Prognostic Factor Studies. 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