{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:38:30Z","timestamp":1791409110897,"version":"4.3.3"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fetal neonatal alloimmune thrombocytopenia (<jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content>) is a devastating bleeding disorder in the fetus or neonate caused by transplacental transport of maternal alloantibodies to paternal\u2010derived antigen on fetal platelets. In <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasians, up to 80% of <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content> cases result from maternal immunization to human platelet antigen (<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>)\u20101a. New methods have developed facilitating detection of common and private antibodies against <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>s triggering <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content>. Understanding the pathogenesis of <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content> made it possible to develop a novel strategy to treat this disorder. To date, recombinant monoclonal antibodies directed against the \u03b23 integrin and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>c receptors have been tested in a mouse model of <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content>, and seem to be promising. Whether those novel treatments will eventually replace the conventional high dose immunoglobulin <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> in women with <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content> is yet unknown.<\/jats:p>","DOI":"10.1111\/bjh.12372","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T12:04:38Z","timestamp":1368533078000},"page":"304-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Predicting risk severity and response of fetal neonatal alloimmune thrombocytopenia"],"prefix":"10.1111","volume":"162","author":[{"given":"Ophira","family":"Salomon","sequence":"first","affiliation":[{"name":"Amalia Biron Research Institute of Thrombosis and Haemostasis Sheba Medical Center Tel Hashomer and Sackler Faculty of Medicine Tel Aviv University Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurit","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Amalia Biron Research Institute of Thrombosis and Haemostasis Sheba Medical Center Tel Hashomer and Sackler Faculty of Medicine Tel Aviv University Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01244.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-026419"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318242a11d"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-211839"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01274.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01972.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03171.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000192404.25780.68"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01291.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04408.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03380.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.03.011"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08892.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-284919"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02977.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00176.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4402"},{"key":"e_1_2_11_19_1","first-page":"2929","article-title":"Developing recombinant HPA\u20101a\u2010specific antibodies with abrogated Fc\u03b3 receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia","volume":"118","author":"Ghevaert C.","year":"2008","journal-title":"The Journal of Clinical Investigation"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02246.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.025106"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.10.015"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613331"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1182\/blood.V84.6.1851.1851","article-title":"Fetal thrombocytopenia: a retrospective survey of 5194 fetal blood samplings","volume":"84","author":"Hohlfeld P.","year":"1994","journal-title":"Blood"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2779"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02657.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41030375.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00606.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2235"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12515"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040121"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328358f86c"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08540.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03491.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1160\/TH05-03-0159","article-title":"Functional heterogeneity of alloantibdies against the human platelet antigen (HPA)\u2010Ia","volume":"94","author":"Kroll H.","year":"2005","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01832.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02862.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03039.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537\u20102995.2012.03954.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/384685"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03734.x"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2422060133"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2011.01358.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2003.00331.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114082"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31823403f4"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90559-6"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02438.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03428.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537\u20102995.2012.03903.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12235"},{"issue":"1","key":"e_1_2_11_52_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/AOG.0b013e3182765c63","article-title":"Maternal hemolysis after intravenous immunoglobulin treatment in fetal and neonatal alloimmune thrombocytopenia","volume":"121","author":"Rink B.D.","year":"2013","journal-title":"Obstetrics and Gynecoogyl"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1004"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03304.x"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-08-0542"},{"key":"e_1_2_11_56_1","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1182\/blood.V94.12.4103","article-title":"A point mutation Thr(799)Met on the alpha(2) integrin \u2018 of new human platelet alloantigen Sit(a) and affects collagen\u2010induced aggregation","volume":"84","author":"Santoso S.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1205"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03039.x"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02065.x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01093.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.051276"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02068.x"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03480.x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.030148"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.06.066"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12372","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:02:20Z","timestamp":1696291340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,14]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/bjh.12372"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12372","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,14]]},"assertion":[{"value":"2013-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}