{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:43:35Z","timestamp":1791359015327,"version":"4.3.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid of The Ministry of Education, Science, Sports"},{"name":"Ministry of Health, Labour, and Welfare, Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Summary<\/jats:title>\n \n CD<\/jats:styled-content>\n 26 (\n DPP<\/jats:styled-content>\n 4) is a\n T<\/jats:styled-content>\n cell costimulatory molecule as well as\n T<\/jats:styled-content>\n cell activation marker, and\n CD<\/jats:styled-content>\n 26\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells are accumulated in inflamed tissues, such as rheumatoid synovitis and autoimmune thyroiditis. In the present study, we found accumulation of\n CD<\/jats:styled-content>\n 26\n +<\/jats:sup>\n T<\/jats:styled-content>\n cells in graft\u2010versus\u2010host disease (\n GVHD<\/jats:styled-content>\n ) target organs. To expand our\n in vitro<\/jats:italic>\n findings to an\n in vivo<\/jats:italic>\n system, we examined\n CD<\/jats:styled-content>\n 26\u2010dependent organ injury in a xenogeneic\n GVHD<\/jats:styled-content>\n (x\u2010\n GVHD<\/jats:styled-content>\n ) murine model. Following intraperitoneal injection of human peripheral blood mononuclear cells into non\u2010obese diabetic severe combined immunodeficiency\/\u03b3\n c<\/jats:sub>\n \u2212\/\u2212<\/jats:sup>\n mice (hu\u2010\n PBL<\/jats:styled-content>\n \u2010\n NOG<\/jats:styled-content>\n mice), the mice exhibited the onset of\n GVHD<\/jats:styled-content>\n symptoms associated with the presence of\n CD<\/jats:styled-content>\n 26\n high<\/jats:sup>\n human lymphocytes in the peripheral blood and\n GVHD<\/jats:styled-content>\n target tissues. Administration of humanized anti\u2010human\n CD<\/jats:styled-content>\n 26 monoclonal antibody (\n mA<\/jats:styled-content>\n b) decreased x\u2010\n GVHD<\/jats:styled-content>\n severity and prolonged survival in hu\u2010\n PBL<\/jats:styled-content>\n \u2010\n NOG<\/jats:styled-content>\n mice without loss of engraftment of human\n T<\/jats:styled-content>\n cells, while increasing doses of\n CTLA<\/jats:styled-content>\n 4\u2010 immunoglobulin fusion protein diminished engraftment of human lymphocytes. Importantly, anti\u2010\n CD<\/jats:styled-content>\n 26\n mA<\/jats:styled-content>\n b treatment preserved the graft\u2010versus\u2010leukaemia effects in studies using cotransplantation of\n P<\/jats:styled-content>\n 815 murine leukaemic cells. In addition,\n CD<\/jats:styled-content>\n 26\n +<\/jats:sup>\n lymphocytes infiltrated the\n GVHD<\/jats:styled-content>\n patients' target tissues. Altogether, our data indicate a role for\n CD<\/jats:styled-content>\n 26 in the regulation of\n GVHD<\/jats:styled-content>\n and point to\n CD<\/jats:styled-content>\n 26 as a novel target for therapeutic intervention in this disease.\n <\/jats:p>","DOI":"10.1111\/bjh.12378","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T08:29:12Z","timestamp":1369124952000},"page":"263-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Prevention of acute graft\u2010versus\u2010host disease by humanized anti\u2010\n CD<\/scp>\n 26 monoclonal antibody"],"prefix":"10.1111","volume":"162","author":[{"given":"Ryo","family":"Hatano","sequence":"first","affiliation":[{"name":"Department of Therapy Development and Innovation for Immune disorders and Cancers Graduate School of Medicine Juntendo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Ohnuma","sequence":"additional","affiliation":[{"name":"Department of Therapy Development and Innovation for Immune disorders and Cancers Graduate School of Medicine Juntendo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Therapy Development and Innovation for Immune disorders and Cancers Graduate School of Medicine Juntendo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam H.","family":"Dang","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikao","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Therapy Development and Innovation for Immune disorders and Cancers Graduate School of Medicine Juntendo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1990"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000206319"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103801"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.4049\/jimmunol.159.7.3460","article-title":"CD28\/B7 interactions are required for sustaining the graft\u2010versus\u2010leukemia effect of delayed post\u2010bone marrow transplantation splenocyte infusion in murine recipients of myeloid or lymphoid leukemia cells","volume":"159","author":"Blazar B.R.","year":"1997","journal-title":"Journal of Immunology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3212"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/976793"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097071"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.4049\/jimmunol.145.12.3963","article-title":"Cell surface modulation of CD26 by anti\u20101F7 monoclonal antibody. Analysis of surface expression and human T cell activation","volume":"145","author":"Dang N.H.","year":"1990","journal-title":"Journal of Immunology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(98)80013-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.4049\/jimmunol.142.12.4233","article-title":"Increment in the Ta1+ cells in the peripheral blood and thyroid tissue of patients with Graves' disease","volume":"142","author":"Eguchi K.","year":"1989","journal-title":"Journal of Immunology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/302172"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60237-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.4049\/jimmunol.133.3.1250","article-title":"Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody","volume":"133","author":"Fox D.A.","year":"1984","journal-title":"Journal of Immunology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050524"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0091"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.3201"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.11.4887.bloodjournal87114887"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198505303122201"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12028"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02899.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0207"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108188"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.137"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X653110"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1323143"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1016\/S0021-9258(18)45862-0","article-title":"cDNA cloning for mouse thymocyte\u2010activating molecule. A multifunctional ecto\u2010dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases","volume":"267","author":"Marguet D.","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.4049\/jimmunol.148.5.1367","article-title":"Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro","volume":"148","author":"Masuyama J.","year":"1992","journal-title":"Journal of Immunology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80494-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.342"},{"key":"e_1_2_8_31_1","first-page":"2022","article-title":"Increased population of high fluorescence 1F7 (CD26) antigen on T cells in synovial fluid of patients with rheumatoid arthritis","volume":"23","author":"Mizokami A.","year":"1996","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01571.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.4049\/jimmunol.143.11.3430","article-title":"1F7, a novel cell surface molecule, involved in helper function of CD4 cells","volume":"143","author":"Morimoto C.","year":"1989","journal-title":"Journal of Immunology"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06134.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2002.01510.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.02.010"},{"key":"e_1_2_8_37_1","first-page":"87","article-title":"2010 report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders","volume":"2010","author":"Pasquini M.C.","year":"2010","journal-title":"Clinical Transplants"},{"key":"e_1_2_8_38_1","first-page":"825","article-title":"1994 consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka D.","year":"1995","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00770.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.4049\/jimmunol.160.9.4225","article-title":"Involvement of CD40 ligand\u2010CD40 and CTLA4\u2010B7 pathways in murine acute graft\u2010versus\u2010host disease induced by allogeneic T cells lacking CD28","volume":"160","author":"Saito K.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_8_41_1","first-page":"621","article-title":"The skin biopsy in the diagnosis of acute graft\u2010versus\u2010host disease in man","volume":"89","author":"Sale G.E.","year":"1977","journal-title":"American Journal of Pathology"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2000"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03470.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4049\/jimmunol.149.2.481","article-title":"Cloning and functional expression of the T cell activation antigen CD26","volume":"149","author":"Tanaka T.","year":"1992","journal-title":"Journal of Immunology"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.12.14"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.03005.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.04.001"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0873"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323469"},{"key":"e_1_2_8_50_1","first-page":"2052","article-title":"Infusion of CD4+ donor lymphocytes induces the expansion of CD8+ donor T cells with cytolytic activity directed against recipient hematopoietic cells","volume":"8","author":"Zorn E.","year":"2002","journal-title":"Clinical Cancer Research"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12378","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:50:53Z","timestamp":1696305053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,21]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/bjh.12378"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12378","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,21]]},"assertion":[{"value":"2013-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}