{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:31:24Z","timestamp":1789900284738,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,29]],"date-time":"2013-06-29T00:00:00Z","timestamp":1372464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>An increased number of circulating monocytes at presentation has recently been associated with shorter survival in Hodgkin lymphoma, follicular lymphoma and diffuse large B cell lymphoma. This study aimed to assess the prognostic impact of the absolute monocyte count (<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>) at diagnosis in mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> at diagnosis was available in 97 <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> cases recorded in the databases of the Oncology Institute of Southern Switzerland in Bellinzona (Switzerland) and the Division of Haematology of the Amedeo Avogadro University of Eastern Piedmont in Novara (Italy). With a median follow up of 7\u00a0years, the 5\u2010year overall survival was 29% for patients with <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> &gt;0\u00b750\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l and 62% for patients with <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> \u22640\u00b750\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7008). Elevated <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> and beta\u20102 microglobulin at diagnosis remained independent outcome predictors at multivariate analysis, controlling for the <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> International Prognostic Index (<jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>), and have been used to build a simple prognostic scoring system. In this relatively small and heterogeneous series an increased <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> identified poor\u2010risk patients. Our results suggest that <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> together with the beta\u20102 microglobulin level might provide an inexpensive way to stratify <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> patient risk as a complement to the <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content>, which was confirmed to be a very powerful prognostic tool.<\/jats:p>","DOI":"10.1111\/bjh.12409","type":"journal-article","created":{"date-parts":[[2013,6,29]],"date-time":"2013-06-29T07:38:56Z","timestamp":1372491536000},"page":"465-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Prognostic impact of monocyte count at presentation in mantle cell lymphoma"],"prefix":"10.1111","volume":"162","author":[{"given":"Kathrin","family":"Aprile von Hohenstaufen","sequence":"first","affiliation":[{"name":"IOSI \u2013 Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Conconi","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0 Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassio Polpo","family":"de Campos","sequence":"additional","affiliation":[{"name":"Dalle Molle Institute for Artificial Intelligence Manno\u2010Lugano Switzerland"},{"name":"Lymphoma &amp; Genomics Research Program IOR Institute of Oncology Research Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Franceschetti","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0 Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bertoni","sequence":"additional","affiliation":[{"name":"IOSI \u2013 Oncology Institute of Southern Switzerland Bellinzona Switzerland"},{"name":"Lymphoma &amp; Genomics Research Program IOR Institute of Oncology Research Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Margiotta Casaluci","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0 Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Stathis","sequence":"additional","affiliation":[{"name":"IOSI \u2013 Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Ghielmini","sequence":"additional","affiliation":[{"name":"IOSI \u2013 Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Stussi","sequence":"additional","affiliation":[{"name":"IOSI \u2013 Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Cavalli","sequence":"additional","affiliation":[{"name":"IOSI \u2013 Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0 Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Zucca","sequence":"additional","affiliation":[{"name":"IOSI \u2013 Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04515.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.364"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e318223ef29"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr157"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.767"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2011.09.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-115915"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-0123-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.8298"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.767454"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03706.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041869"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.179"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1565"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-236570"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-179739"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.9881"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370908"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02268.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095331"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25969"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13574"},{"key":"e_1_2_9_26_1","volume-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch J.D.","year":"1980"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701665954"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0034"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802885"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041658"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2011.03.010"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.6121"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0706481"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-400580"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-189977"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2010.00235.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.050138"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.690605"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09067.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905680"},{"key":"e_1_2_9_42_1","first-page":"229","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S.H.","year":"2008"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2019"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0778"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087882"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-010-0093-6"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04096.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2487"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-220111"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.112"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.637211"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1140-8"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a059155"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:00:22Z","timestamp":1696280422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,29]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/bjh.12409"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12409","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,29]]},"assertion":[{"value":"2013-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}