{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:11:23Z","timestamp":1791295883340,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,15]],"date-time":"2013-06-15T00:00:00Z","timestamp":1371254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Summary<\/jats:title>\n \n In tumour lysis syndrome (\n TLS<\/jats:styled-content>\n ), metabolic alterations caused by the destruction of malignant cells manifest as laboratory abnormalities with (clinical\n TLS<\/jats:styled-content>\n ) or without (laboratory\n TLS<\/jats:styled-content>\n ) organ dysfunction. This prospective multicentre cohort study included 153 consecutive patients with malignancies at high risk for\n TLS<\/jats:styled-content>\n (median age 54\u00a0years (interquartile range, 38\u201366). Underlying malignancies were acute leukaemia (58%), aggressive non\u2010Hodgkin lymphoma (29.5%), and Burkitt leukaemia\/lymphoma (12.5%). Laboratory\n TLS<\/jats:styled-content>\n developed in 17 (11.1%) patients and clinical\n TLS<\/jats:styled-content>\n with acute kidney injury (\n AKI<\/jats:styled-content>\n ) in 30 (19.6%) patients. After adjustment for confounders, admission phosphates level (odds ratio [\n OR<\/jats:styled-content>\n ] per mmol\/l, 5.3; 95% confidence interval [95%\n CI<\/jats:styled-content>\n ], 1.5\u201318.3), lactic dehydrogenase (\n OR<\/jats:styled-content>\n per x normal, 1.1; 95%\n CI<\/jats:styled-content>\n , 1.005\u20131.25), and disseminated intravascular coagulation (\n OR<\/jats:styled-content>\n , 4.1; 95%\n CI<\/jats:styled-content>\n , 1.4\u201312.3) were associated with clinical\n TLS<\/jats:styled-content>\n ; and\n TLS<\/jats:styled-content>\n was associated with day\u201090 mortality (\n OR<\/jats:styled-content>\n , 2.45; 95%\n CI<\/jats:styled-content>\n , 1.09\u20135.50;\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.03). In this study,\n TLS<\/jats:styled-content>\n occurred in 30.7% of high\u2010risk patients. One third of all patients experienced\n AKI<\/jats:styled-content>\n , for which\n TLS<\/jats:styled-content>\n was an independent risk factor.\n TLS<\/jats:styled-content>\n was associated with increased mortality, indicating a need for interventional studies aimed at decreasing early\n TLS<\/jats:styled-content>\n \u2010related deaths in this setting.\n <\/jats:p>","DOI":"10.1111\/bjh.12415","type":"journal-article","created":{"date-parts":[[2013,6,15]],"date-time":"2013-06-15T03:37:38Z","timestamp":1371267458000},"page":"489-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Tumour lysis syndrome and acute kidney injury in high\u2010risk haematology patients in the rasburicase era. A prospective multicentre study from the Groupe de Recherche en\n R<\/scp>\n \u00e9animation Respiratoire et\n O<\/scp>\n nco\u2010\n H<\/scp>\n \u00e9matologique"],"prefix":"10.1111","volume":"162","author":[{"given":"Michael","family":"Darmon","sequence":"first","affiliation":[{"name":"Medical\u2010Surgical ICU Saint\u2010Etienne University Hospital Saint\u2010Priest\u2010en\u2010Jarez France"},{"name":"Jean Monnet University Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Vincent","sequence":"additional","affiliation":[{"name":"Medical Surgical ICU Avicenne University Hospital Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Camous","sequence":"additional","affiliation":[{"name":"Medical ICU Bic\u00eatre University Hospital Le Kremlin\u2010Bic\u00eatre France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de 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