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This investigator\u2010initiated, non\u2010randomized, open\u2010label phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> multi\u2010centre study included 63 patients (19 essential thrombocythaemia, 44 polycythaemia vera) from 15 centres. The primary objective was to evaluate if vorinostat was followed by a decline in clonal myeloproliferation as defined by <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eukaemia <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>et. Thirty patients (48%) completed the intervention period (24\u00a0weeks of therapy). An intention\u2010to\u2010treat response rate of 35% was identified. Pruritus was resolved [19% to 0% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b706)] and the prevalence of splenomegaly was lowered from 50% to 27% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703). Sixty\u2010five per cent of the patients experienced a decrease in <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic> V617F allele burden (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006). Thirty\u2010three patients (52% of patients) discontinued study drug before end of intervention due to adverse events (28 patients) or lack of response (5 patients). In conclusion, vorinostat showed effectiveness by normalizing elevated leucocyte and platelet counts, resolving pruritus and significantly reducing splenomegaly. However, vorinostat was associated with significant side effects resulting in a high discontinuation rate. A lower dose of vorinostat in combination with conventional and\/or novel targeted therapies may be warranted in future studies.<\/jats:p>","DOI":"10.1111\/bjh.12416","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T12:38:23Z","timestamp":1370954303000},"page":"498-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["A phase II study of vorinostat (<scp>MK<\/scp>\u20100683) in patients with polycythaemia vera and essential thrombocythaemia"],"prefix":"10.1111","volume":"162","author":[{"given":"Christen L.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Haematology Roskilde Hospital Roskilde Denmark"},{"name":"Department of Haematology Copenhagen University Hospital Rigshospitalet Copenhagen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary F.","family":"McMullin","sequence":"additional","affiliation":[{"name":"Department of 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