{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T22:52:25Z","timestamp":1787179945756,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Ectopic viral integration site\u20101 (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1)\n                    <\/jats:italic>\n                    is highly expressed in certain cytogenetic subsets of adult acute myeloid leukaemia (\n                    <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                    ), and has been associated with inferior survival. We sought to examine the clinical and biological associations of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    <jats:sup>high<\/jats:sup>\n                    , defined as expression in excess of normal controls, in paediatric\n                    <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                    .\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    expression was measured via quantitative real\u2010time polymerase chain reaction in diagnostic specimens obtained from 206 patients. Expression levels were correlated with clinical features and outcome.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    <jats:sup>high<\/jats:sup>\n                    was present in 58\/206 (28%) patients.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content>\n                    <\/jats:italic>\n                    rearrangements occurred in 40% of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    <jats:sup>high<\/jats:sup>\n                    patients as opposed to 12% of the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    <jats:sup>low\/absent<\/jats:sup>\n                    patients (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b7001). No abnormalities of 3q26 were found in\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    <jats:sup>high<\/jats:sup>\n                    patients by conventional cytogenetic analysis, nor were cryptic 3q26 abnormalities detected in a subset of patients screened by next\u2010generation sequencing. French\u2010American\u2010British class M7 was enriched in the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    <jats:sup>high<\/jats:sup>\n                    group, accounting for 24% of these patients.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    <jats:sup>high<\/jats:sup>\n                    patients had significantly lower 5\u2010year overall survival from study entry (51% vs. 68%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7015). However, in multivariate analysis including other established prognostic markers,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    expression did not retain independent prognostic significance.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    expression is currently being studied in a larger cohort of patients enrolled on subsequent Children's Oncology Group trials, to determine if\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">EVI<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    <jats:sup>high<\/jats:sup>\n                    has prognostic value in\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">MLL<\/jats:styled-content>\n                      \u2010\n                    <\/jats:italic>\n                    rearranged or intermediate\u2010risk subsets.\n                  <\/jats:p>","DOI":"10.1111\/bjh.12444","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T08:43:26Z","timestamp":1372927406000},"page":"670-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["High\n                    <i>\n                      <scp>EVI<\/scp>\n                      1\n                    <\/i>\n                    expression is associated with\n                    <i>\n                      <scp>MLL<\/scp>\n                    <\/i>\n                    rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's oncology group"],"prefix":"10.1111","volume":"162","author":[{"given":"Phoenix A.","family":"Ho","sequence":"first","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Pediatric Hematology\/Oncology Seattle Children's Hospital University of Washington School of Medicine Seattle WA USA"},{"name":"Children's Oncology Group Arcadia CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Alonzo","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Arcadia CA USA"},{"name":"Department of Biostatistics University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Gerbing","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Arcadia CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Pollard","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Pediatric Hematology\/Oncology Seattle Children's Hospital University of Washington School of Medicine Seattle WA USA"},{"name":"Children's Oncology Group Arcadia CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Arcadia CA USA"},{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Cancer Center Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana C.","family":"Raimondi","sequence":"additional","affiliation":[{"name":"Children's Oncology Group Arcadia CA USA"},{"name":"Department of Pathology St. Jude Children's Research Hospital Memphis TN 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