{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:00:51Z","timestamp":1791320451711,"version":"4.3.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso\u2010occlusive crisis (<jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>) [<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7028, odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>); 2\u00b705, 95% Confidence Interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u00a0=\u00a01\u00b708\u20133\u00b789] and acute chest syndrome (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) [<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7016, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>; 2\u00b756, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01\u00b719, 5\u00b747], after adjusting for age and gender in children with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/bjh.12445","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T05:04:58Z","timestamp":1372309498000},"page":"702-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Association between plasma free haem and incidence of vaso\u2010occlusive episodes and acute chest syndrome in children with sickle cell disease"],"prefix":"10.1111","volume":"162","author":[{"given":"Olufolake A.","family":"Adisa","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology and Bone Marrow Transplantation Department of Pediatrics Emory University School of Medicine Emory University Atlanta GA USA"},{"name":"Aflac Cancer Center and Blood Disorders Service Children's Healthcare of Atlanta Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Rollins School of Public Health Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samit","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Bone Marrow Transplantation Department of Pediatrics Emory University School of Medicine Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Aryee","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Bone Marrow Transplantation Department of Pediatrics Emory University School of Medicine Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeyinwa","family":"Osunkwo","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Bone Marrow Transplantation Department of Pediatrics Emory University School of Medicine Emory University Atlanta GA USA"},{"name":"Aflac Cancer Center and Blood Disorders Service Children's Healthcare of Atlanta Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon F.","family":"Ofori\u2010Acquah","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Bone Marrow Transplantation Department of Pediatrics Emory University School of Medicine Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-361642"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0021-9258(18)93628-8","article-title":"Exchange of heme among hemoglobins and between hemoglobin and albumin","volume":"243","author":"Bunn H.F.","year":"1968","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-268193"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.2.643.643"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1182\/blood.V116.21.944.944","article-title":"Acute chest syndrome in transgenic mouse models of sickle cell disease triggered by free heme","volume":"116","author":"Ghosh S.","year":"2010","journal-title":"Blood"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035477"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.3.879"},{"key":"e_1_2_6_9_1","first-page":"1550","article-title":"Safety of hydroxyurea in children with sickle cell anemia: results of the HUG\u2010KIDS study, a phase I\/II trial. 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