{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:03:49Z","timestamp":1778947429028,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,6]],"date-time":"2013-07-06T00:00:00Z","timestamp":1373068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Low doses of the humanized anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 monoclonal antibody, veltuzumab, were evaluated in 41 patients with immune thrombocytopenia (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>), including 9 with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> \u22641\u00a0year duration previously treated with steroids and\/or immunoglobulins, and 32 with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> &gt;1\u00a0year and additional prior therapies. They received two doses of 80\u2013320\u00a0mg veltuzumab 2\u00a0weeks apart, initially by intravenous (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) infusion (N\u00a0=\u00a07), or later by subcutaneous (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) injections (N\u00a0=\u00a034), with only one Grade 3 infusion reaction and no other safety issues. Thirty\u2010eight response\u2010assessable patients had 21 (55%) objective responses (platelet count \u226530\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l and \u22652\u00a0\u00d7\u00a0baseline), including 11 (29%) complete responses (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>s) (platelet count \u2265100\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l). Responses (including <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>s) occurred with both <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> administration, at all veltuzumab dose levels, and regardless of <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> duration. Responders with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> \u22641\u00a0year had a longer median time to relapse (14\u00b74\u00a0months) than those with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> &gt;1\u00a0year (5\u00b78\u00a0months). Three patients have maintained a response for up to 4\u00b73\u00a0years. <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> injections resulted in delayed and lower peak serum levels of veltuzumab, but B\u2010cell depletion occurred after first administration even at the lowest doses. Eight patients, including 6 responders, developed anti\u2010veltuzumab antibodies following treatment (human anti\u2010veltuzumab antibody, 19\u00b75%). Low\u2010dose <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> veltuzumab appears convenient, well\u2010tolerated, and with promising clinical activity in relapsed <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>.(<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> identifier: NCT00547066.)<\/jats:p>","DOI":"10.1111\/bjh.12448","type":"journal-article","created":{"date-parts":[[2013,7,6]],"date-time":"2013-07-06T15:12:42Z","timestamp":1373123562000},"page":"693-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Low\u2010dose anti\u2010<scp>CD<\/scp>20 veltuzumab given intravenously or subcutaneously is active in relapsed immune thrombocytopenia: a phase I study"],"prefix":"10.1111","volume":"162","author":[{"given":"Howard A.","family":"Liebman","sequence":"first","affiliation":[{"name":"Internal Medicine Jane Anne Nohl Division of Hematology Keck School of Medicine of University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansoor N.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Georgia Cancer Specialists Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Bussel","sequence":"additional","affiliation":[{"name":"Platelet Disorders Center Division of Pediatric Hematology\u2010Oncology NY Presbyterian Hospital New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidiu George","family":"Negrea","sequence":"additional","affiliation":[{"name":"Low Country Cancer Care Associates Savannah GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Horne","sequence":"additional","affiliation":[{"name":"Immunomedics, Inc. Morris Plains NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Wegener","sequence":"additional","affiliation":[{"name":"Immunomedics, Inc. Morris Plains NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Immunomedics, Inc. 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