{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T15:38:53Z","timestamp":1707925133988},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,6]],"date-time":"2013-07-06T00:00:00Z","timestamp":1373068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The treatment outcome of children with refractory acute leukaemia or relapse post\u2010stem cell transplantation is dismal. We report 10 children (non\u2010remission <jats:italic>n<\/jats:italic>\u00a0=\u00a07) who underwent a new haploidentical transplant approach utilizing unmanipulated bone marrow followed by <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>6\u2010depleted peripheral blood stem cells. Nine patients had successful engraftment and no evidence of leukaemia. Acute and chronic graft\u2010versus\u2010host\u2010disease was observed in five and three patients, respectively; two patients died of treatment\u2010related toxicity. Seven patients relapsed after 7 (range 3\u201334) months, however two patients are alive at 6\u00b75 and 7\u00b70\u00a0years. This approach provides anti\u2010leukaemic activity even in heavily pre\u2010treated children but long\u2010term disease control requires further intervention.<\/jats:p>","DOI":"10.1111\/bjh.12455","type":"journal-article","created":{"date-parts":[[2013,7,6]],"date-time":"2013-07-06T14:14:53Z","timestamp":1373120093000},"page":"802-807","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010leukaemic activity of a novel haploidentical\u2010transplantation approach employing unmanipulated bone marrow followed by <scp>CD<\/scp>6\u2010depleted peripheral blood stem cells in children with refractory\/relapsed acute leukaemia"],"prefix":"10.1111","volume":"162","author":[{"given":"Friedhelm R.","family":"Schuster","sequence":"first","affiliation":[{"name":"Clinic of Paediatric Oncology, Haematology and Clinical Immunology Centre for Child and Adolescent Health Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Meisel","sequence":"additional","affiliation":[{"name":"Clinic of Paediatric Oncology, Haematology and Clinical Immunology Centre for Child and Adolescent Health Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"F\u00fchrer","sequence":"additional","affiliation":[{"name":"Dr. von Haunersches Kinderspital Ludwig\u2010Maximilians\u2010Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Reuther","sequence":"additional","affiliation":[{"name":"Clinic of Paediatric Oncology, Haematology and Clinical Immunology Centre for Child and Adolescent Health Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf D\u00fcsseldorf 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