{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:33:51Z","timestamp":1790746431717,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,13]],"date-time":"2013-07-13T00:00:00Z","timestamp":1373673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Myeloproliferative neoplasm\u2010related myelofibrosis is associated with cytopenic or proliferative phases, splenomegaly and constitutional symptoms. Few effective treatments are available and small series suggested that interferon could be an option for myelofibrosis therapy. We performed a retrospective study of pegylated\u2010interferon \u03b1\u20102a (Peg\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b1\u20102a) therapy in myelofibrosis. Sixty\u2010two patients treated with Peg\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b1\u20102a at 17 French and Belgian centres were included. Responses were determined based on the criteria established by the International Working Group for Myelofibrosis Research and Treatment. Mean follow\u2010up was 26\u00a0months. Sixteen of 25 anaemic patients (64%) (eight concomitantly receiving recombinant erythropoietin) achieved a complete response and transfusion\u2010independence was obtained in 5\/13 patients (38\u00b75%). Constitutional symptoms resolved in 82% of patients. All five leucopenic patients normalized their leucocyte counts, whereas a normal platelet count was obtained in 5\/8 thrombocytopenic patients. Splenomegaly was reduced in 46\u00b75% of patients, and complete resolution of thrombocytosis and leucocytosis were observed in 82\u00b78% and 68\u00b78% of patients, respectively. Side effects (mostly haematological) were mainly of grade 1\u20132. The only factor independently associated with treatment failure was a spleen enlargement of more than 6\u00a0cm below the costal margin. In conclusion, Peg\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b1\u20102a induced high response rates with acceptable toxicity in a large proportion of patients with primary and secondary myelofibrosis, especially in early phases.<\/jats:p>","DOI":"10.1111\/bjh.12459","type":"journal-article","created":{"date-parts":[[2013,7,13]],"date-time":"2013-07-13T07:35:05Z","timestamp":1373700905000},"page":"783-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Efficacy and safety of pegylated\u2010interferon \u03b1\u20102a in myelofibrosis: a study by the <scp>FIM<\/scp> and <scp>GEM<\/scp> French cooperative groups"],"prefix":"10.1111","volume":"162","author":[{"given":"Jean\u2010Christophe","family":"Ianotto","sequence":"first","affiliation":[{"name":"Service d'h\u00e9matologie clinique Institut de Canc\u00e9ro\u2010H\u00e9matologie CHRU Brest Brest 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