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Although <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> are common causes of <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>, the pathophysiological mechanisms underlying this predisposition, their epidemiology and natural history are not fully understood. Studies have concentrated on the generalized prothrombotic environment generated by <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> and their relationship with abnormal blood counts, thereby furthering our knowledge of arterial and venous thrombosis in this population. In contrast, there are few studies that have specifically addressed <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> in the context of <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>. Recent research has demonstrated in patients with <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> the existence of factors increasing the risk of <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> such as the presence of the <jats:styled-content style=\"fixed-case\"><jats:italic>JAK2<\/jats:italic> V<\/jats:styled-content>617<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content> mutation and its 46\/1 haplotype. Features unique to the circulating blood cells, splanchnic vasculature and surrounding micro\u2010environment in patients with <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> have been described. There are also abnormalities in local haemodynamics, haemostatic molecules, the spleen, and splanchnic endothelial and endothelial progenitor cells. This review considers these important advances and discusses the contribution of individual anomalies that lead to the development of <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> in both the pre\u2010neoplastic and overt stage of <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>. Clinical issues relating to epidemiology, recurrence and survival in these patients have also been reviewed and their results discussed.<\/jats:p>","DOI":"10.1111\/bjh.12461","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T11:56:37Z","timestamp":1373889397000},"page":"730-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Splanchnic vein thrombosis in myeloproliferative neoplasms"],"prefix":"10.1111","volume":"162","author":[{"given":"Mallika","family":"Sekhar","sequence":"first","affiliation":[{"name":"Department of Haematology Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"McVinnie","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Medical School London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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