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To this day, however, it is unclear whether the immune abnormalities associated with<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>play causative roles in the disease or are secondary epiphenomena brought on by the inflammatory processes that are associated with the disorder. Like the majority of all autoimmune diseases,<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>is an organ\u2010specific disease and abnormalities in immune cell types, such as antigen\u2010presenting cells (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>),<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>cells and<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>cells have been shown to play some sort of role in the initiation and\/or perpetuation of the disease. This review will discuss recent advances in understanding three immune cells important in<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>pathophysiology:<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>, T cells and B cells, and will review how they interact with each other to initiate and perpetuate<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>, particularly the chronic form of the disorder. It will also focus on new data related to the genetics of the disorder and discuss relevant animal models of<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.12480","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T12:57:37Z","timestamp":1376312257000},"page":"10-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":164,"title":["Cellular immune dysfunction in immune thrombocytopenia (<scp>ITP<\/scp>)"],"prefix":"10.1111","volume":"163","author":[{"given":"Christopher G. 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