{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:05:22Z","timestamp":1790384722695,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) is a disorder known to impact the respiratory system. We sought to identify respiratory muscle force and lung volume relationships in a paediatric <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> population. Thirty\u2010four <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> subjects underwent pulmonary function testing. Height, weight, age, and gender\u2010adjusted percent predicted maximal inspiratory pressure (<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>) and maximal expiratory pressure (<jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content>) values were compared to spirometry and lung volumes. Statistical analyses were performed using <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>earson's correlation coefficient and paired two\u2010tailed t\u2010test. The mean\u00a0\u00b1\u00a0standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content> was 69\u00b76\u00a0\u00b1\u00a031\u00b76\u00a0cm H<jats:sub>2<\/jats:sub>O and 66\u00b79\u00a0\u00b1\u00a022\u00b79\u00a0cm H<jats:sub>2<\/jats:sub>O, respectively, and mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> percent predicted <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content> (101\u00b73\u00a0\u00b1\u00a045\u00b79) exceeded <jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content> (72\u00b71\u00a0\u00b1\u00a026\u00b70) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002). <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content> correlated with forced vital capacity (<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>;<jats:italic> r<\/jats:italic>\u00a0=\u00a00\u00b751, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001) and <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b754, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001). <jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content> also correlated with <jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b743, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7011) and total lung capacity (<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>;<jats:italic> r<\/jats:italic>\u00a0=\u00a00\u00b742, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7013). Pearson's correlation coefficient testing yielded relationships between <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MEP<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b764, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001). <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> patients showed correlations between respiratory muscle force and lung volume, and reduced percent predicted expiratory muscle force compared to inspiratory muscle force. Respiratory muscle strength may affect lung volumes in these patients, and expiratory muscles may be more susceptible than the diaphragm to <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\u2010induced vaso\u2010occlusive damage.<\/jats:p>","DOI":"10.1111\/bjh.12481","type":"journal-article","created":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T05:42:53Z","timestamp":1374298973000},"page":"112-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Respiratory muscle force and lung volume changes in a population of children with sickle cell disease"],"prefix":"10.1111","volume":"163","author":[{"given":"Bruce A.","family":"Ong","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology Tripler Army Medical Center Honolulu HI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Caboot","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology Madigan Army Medical Center Ft. Lewis WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Jawad","sequence":"additional","affiliation":[{"name":"Division of Biostatistics The Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"McDonough","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine The Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannoa","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Hematology The Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Arens","sequence":"additional","affiliation":[{"name":"Division of Respiratory and Sleep Medicine The Children's Hospital at Montefiore Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole L.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine The Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Smith\u2010Whitley","sequence":"additional","affiliation":[{"name":"Division of Hematology The Children's Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thornton B. 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