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Ovid <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NCBI<\/jats:styled-content> Pubmed were searched systematically for publications in English from 1980 to 2012 using the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content> subheading \u2018lymphoma, <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\u2019, \u2018lymphoma, central nervous system\u2019, \u2018lymphoma, high grade\u2019, \u2018lymphoma, Burkitt's\u2019, \u2018lymphoma, lymphoblastic\u2019 and \u2018lymphoma, diffuse large B cell\u2019 as keywords, as well as all subheadings. The writing group produced the draft guideline, which was subsequently revised by consensus by members of the Haemato\u2010oncology Task Force of the British Committee for Standards in Haematology (<jats:styled-content style=\"fixed-case\">BCSH<\/jats:styled-content>). The guideline was then reviewed by a sounding board of ~50 <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> haematologists, the <jats:styled-content style=\"fixed-case\">BCSH<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ritish <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ociety for <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>aematology (<jats:styled-content style=\"fixed-case\">BSH<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ommittee and comments incorporated where appropriate. The \u2018<jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content>\u2019 system was used to quote levels and grades of evidence, details of which can be found in Appendix I. The objective of this guideline is to provide healthcare professionals with clear guidance on the optimal prevention of secondary central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) lymphoma. The guidance may not be appropriate to patients of all lymphoma sub\u2010types and in all cases individual patient circumstances may dictate an alternative approach. 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