{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:58:05Z","timestamp":1793246285575,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Haematopoietic cell transplantation (<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>) survivors are at increased risk for developing congestive heart failure (<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>), primarily due to pre\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>exposure to anthracyclines. We examined the association between the development of<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>after<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>and polymorphisms in 16 candidate genes involved in anthracycline metabolism, iron homeostasis, anti\u2010oxidant defence, and myocardial remodelling. A nested case\u2010control study design was used. Cases (post\u2010<jats:styled-content style=\"fixed-case\">HCT CHF<\/jats:styled-content>) were identified from 2950 patients who underwent<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>between 1988 and 2007 at<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ity of<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ope and had survived \u22651\u00a0year. This cohort formed the sampling frame for selecting controls (without<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>) matched on: age, race\/ethnicity, cumulative anthracycline exposure, stem cell source (allogeneic, autologous), and length of follow\u2010up. Seventy\u2010seven cases with pre\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>germline<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>and 178 controls were genotyped. Multivariate analysis revealed that the odds of<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>was higher in females [Odds Ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a0=\u00a02\u00b79,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701], individuals with pre\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>chest radiation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a04\u00b77,<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705), hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02\u00b79,<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701), and with variants of genes coding for the<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>(P)H\u2010oxidase subunit<jats:italic><jats:styled-content style=\"fixed-case\">RAC<\/jats:styled-content>2<\/jats:italic>(rs13058338, 7508T\u2192A;<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02\u00b78,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701),<jats:italic><jats:styled-content style=\"fixed-case\">HFE<\/jats:styled-content><\/jats:italic>(rs1799945, 63C\u2192G;<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02\u00b75,<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705) or the doxorubicin efflux transporter<jats:italic><jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>2<\/jats:italic>(rs8187710, 1515G\u2192A;<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a04\u00b73,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701). A combined (clinical and genetic)<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>predictive model performed better [area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>), 0\u00b779] than the genetic (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u00a0=\u00a00\u00b767) or the clinical (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u00a0=\u00a00\u00b769) models alone.<\/jats:p>","DOI":"10.1111\/bjh.12516","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T13:05:18Z","timestamp":1375967118000},"page":"205-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Genetic susceptibility to anthracycline\u2010related congestive heart failure in survivors of haematopoietic cell transplantation"],"prefix":"10.1111","volume":"163","author":[{"given":"Saro H.","family":"Armenian","sequence":"first","affiliation":[{"name":"Department of Population Sciences Outcomes Research City of Hope Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Population Sciences Outcomes Research City of Hope Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Population Sciences Outcomes Research City of Hope Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canlan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Population Sciences Outcomes Research City of Hope Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyanasundaram","family":"Venkataraman","sequence":"additional","affiliation":[{"name":"Department of Medical Specialists, Cardiology City of 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