{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T23:18:14Z","timestamp":1785107894760,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T00:00:00Z","timestamp":1376611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The incidence of essential thrombocythaemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) in children (age \u226418\u00a0years) is extremely low. The natural course of the disorder in children has not been clarified. The rarity of patients and the variability of tested parameters make it difficult to draw any definitive conclusion in pathogenesis and diagnosis of paediatric <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. What makes the onset of thrombocytosis earlier in children is still uncertain. A diagnostic algorithm for paediatric <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> has not been established, and current risk stratification used to guide therapeutic decisions in adults has not been validated in children. Vascular complications and transformation to myelofibrosis and leukaemia in this special entity have been reported, suggesting that <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> in children is not an entirely benign disease. The crucial question is how to identify patients who are at high risk of complications and need treatment. There are insufficient data to recommend a specific agent in children. The purpose of this review is to outline the most recent progress in paediatric <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> and to help with understanding the clinical course, molecular features, diagnosis and treatment strategies in this special group.<\/jats:p>","DOI":"10.1111\/bjh.12530","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T17:22:50Z","timestamp":1376673770000},"page":"295-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Paediatric essential thrombocythaemia: clinical and molecular features, diagnosis and treatment"],"prefix":"10.1111","volume":"163","author":[{"given":"Rongfeng","family":"Fu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Haematology Institute of Haematology and Blood Disease Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 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