{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:33Z","timestamp":1787013933943,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Angiogenesis is involved in the pathogenesis and progression of non\u2010\n                    <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                    odgkin lymphomas (\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    ), and hypoxia\u2010inducible factor\u20101\u03b1 (\n                    <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\n                    \u20101\u03b1, also termed\n                    <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\n                    1\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    ) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    is associated with angiogenesis, and the expression of\n                    <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\n                    \u20101\u03b1 at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed\/refractory indolent\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and\n                    <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\n                    \u20101\u03b1 protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.\n                  <\/jats:p>","DOI":"10.1111\/bjh.12560","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T03:42:00Z","timestamp":1379043720000},"page":"640-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Changes in angiogenesis and hypoxia\u2010inducible factor\u20101\u03b1 protein expression in relapsed\/refractory indolent non\u2010\n                    <scp>H<\/scp>\n                    odgkin lymphomas"],"prefix":"10.1111","volume":"163","author":[{"given":"Carla","family":"Minoia","sequence":"first","affiliation":[{"name":"Haematology Unit Department of Medical and Experimetal Oncology IRCCS National Cancer Research Centre \u201cGiovanni Paolo II\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Quero","sequence":"additional","affiliation":[{"name":"Department of Pathology IRCCS National Cancer Research Centre \u201cGiovanni Paolo II\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaconsilia","family":"Asselti","sequence":"additional","affiliation":[{"name":"Department of Pathology IRCCS National Cancer Research Centre \u201cGiovanni Paolo II\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Galise","sequence":"additional","affiliation":[{"name":"Registro Tumori Puglia IRCCS National Cancer Research Centre \u201cGiovanni Paolo II\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia L.","family":"Marzano","sequence":"additional","affiliation":[{"name":"Department of Pathology 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