{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:06:52Z","timestamp":1773983212374,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>All newly diagnosed patients aged 60\u201379\u00a0years with acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) receiving induction chemotherapy with a modified paediatric\u2010based regimen over a 7\u2010year period were retrospectively analysed (<jats:italic>n<\/jats:italic>\u00a0=\u00a051, median age 65\u00a0years). The treatment regimen consisted of induction, central nervous system prophylaxis, seven cycles of intensification and 24 cycles of maintenance. <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> negative patients received weekly asparaginase during intensification, while <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic>+ patients received daily imatinib. Post\u2010remission therapy was given in an outpatient setting. The complete response rate was 75%, with an induction mortality of 20%; 6% of patients had resistant disease. 37% of patients who achieved a complete remission relapsed. The estimated 5\u2010year overall survival was 40% for <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> negative and 47% for <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic>+ patients (<jats:italic>P\u00a0<\/jats:italic>=\u00a0not significant); the 5\u2010year disease\u2010free survival was 57% and 39%, respectively (<jats:italic>P\u00a0<\/jats:italic>=\u00a0<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). The post\u2010induction phase was generally well tolerated, with 81% able to complete the intensification phase and proceed to maintenance. In conclusion, administration of this modified paediatric\u2010based protocol is feasible and active for elderly patients with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>. Survival is superior to most previously reported series in this age group, but remains worse compared to younger patients. Further improvement of the toxicity profile, particularly during induction, is required to improve outcomes.<\/jats:p>","DOI":"10.1111\/bjh.12561","type":"journal-article","created":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T04:15:11Z","timestamp":1379132111000},"page":"458-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Treatment of elderly patients with acute lymphoblastic leukaemia using a paediatric\u2010based protocol"],"prefix":"10.1111","volume":"163","author":[{"given":"Marc","family":"Poch Martell","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Hematology Princess Margaret Cancer Centre University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eshetu G.","family":"Atenafu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Princess Margaret Cancer Centre University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Minden","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Princess Margaret Cancer Centre University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre C.","family":"Schuh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Princess Margaret Cancer Centre University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen W. 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