{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:23:27Z","timestamp":1777631007081,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Thrombophilia is a well\u2010established risk factor for a venous thromboembolic event (<jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>), and it has been proposed that hereditary thrombophilia may substantially contribute to the development of <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> in young patients. We aimed to analyse the prevalence of thrombophilia with special regard to the age of <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> manifestation. The study cohort consisted of 1490 patients (58% females) with a median age 43\u00a0years at the time of their first <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>. At least one thrombophilic disorder was identified in 50\u00b71% of patients. The probability of detecting a hereditary thrombophilia declined significantly with advancing age (from 49\u00b73% in patients aged 20\u00a0years and younger to 21\u00b79% in patients over the age of 70\u00a0years; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). This may be primarily attributed to the decreasing frequencies of the <jats:italic>F5<\/jats:italic> R506Q (factor <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> Leiden) mutation and deficiencies of protein <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> or protein <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> with older age at the time of the initial <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> event. Moreover, thrombophilia was more prevalent in unprovoked compared with risk\u2010associated <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> (57\u00b77% vs. 47\u00b77%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001). The decline in the prevalence of hereditary thrombophilia with older ages supports the use of a selected thrombophilia screening strategy dependent on age and the presence or absence of additional <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> risk factors.<\/jats:p>","DOI":"10.1111\/bjh.12575","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T05:12:18Z","timestamp":1384319538000},"page":"655-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Prevalence of thrombophilia according to age at the first manifestation of venous thromboembolism: results from the <scp>MAISTHRO<\/scp> registry"],"prefix":"10.1111","volume":"163","author":[{"given":"Lea","family":"Weingarz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Schwonberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Schindewolf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"Hecking","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Erbe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edelgard","family":"Lindhoff\u2010Last","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Linnemann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Vascular Medicine Johann Wolfgang Goethe University Hospital Frankfurt\/Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08022.x"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Interdisziplin\u00e4re S2\u2010Leitlinie: Diagnostik und Therapie der Venenthrombose und der Lungenembolie","volume":"39","author":"Blaettler W.","year":"2010","journal-title":"VASA"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649901"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-06-0364"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3979"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.19.2352"},{"key":"e_1_2_7_8_1","first-page":"2093","article-title":"Early termination of the multicentre randomised clinical trial to evaluate the benefit of testing for thrombophilia following a first venous thromboembolism: the NOSTRADAMUS study","volume":"152","author":"Cohn D.M.","year":"2008","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03005.x"},{"key":"e_1_2_7_10_1","first-page":"pCD007069","article-title":"Thrombophilia testing for prevention of recurrent venous thromboembolism","volume":"1","author":"Cohn D.","year":"2009","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1055\/s-0038-1649589","article-title":"Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. 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