{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:17:45Z","timestamp":1791231465249,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T00:00:00Z","timestamp":1379980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Vitamin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (<jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content>s). Epidemiological studies indicated an association of vitamin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> deficiency with anaemia in humans. To define the requirements of <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content>s in erythropoiesis, we evaluated erythroid parameters in <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content> germ\u2010line deficient and conditional knock out mice with erythroid specific deletion of <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content>s. Adult <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content>\u03b3<jats:sup>\u2212\/<jats:italic>\u2212<\/jats:italic><\/jats:sup> mice were anaemic, however, <jats:italic>Epor\u2010<\/jats:italic>Cre <jats:italic>Rara<\/jats:italic><jats:sup><jats:italic>fl\/fl<\/jats:italic><\/jats:sup>, <jats:italic>Epor<\/jats:italic>\u2010Cre <jats:italic>Rarg<\/jats:italic><jats:sup><jats:italic>fl\/fl<\/jats:italic><\/jats:sup> and <jats:italic>Epor<\/jats:italic>\u2010Cre <jats:italic>Rara<\/jats:italic><jats:sup><jats:italic>fl\/fl<\/jats:italic><\/jats:sup><jats:italic>g<\/jats:italic><jats:sup><jats:italic>fl\/fl<\/jats:italic><\/jats:sup> mice were normal, indicating a lack of an erythroid intrinsic <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content> function. Therefore, erythroid\u2010specific <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content> function is dispensable for erythropoiesis and <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content>\u03b3 plays an erythroid extrinsic role in erythropoiesis.<\/jats:p>","DOI":"10.1111\/bjh.12578","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T00:56:32Z","timestamp":1381539392000},"page":"280-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Erythroid\u2010extrinsic regulation of normal erythropoiesis by retinoic acid receptors"],"prefix":"10.1111","volume":"164","author":[{"given":"Sita R.","family":"Dewamitta","sequence":"first","affiliation":[{"name":"Department of Medicine at St. Vincent's Hospital St. Vincent's Institute of Medical Research University of Melbourne Fitzroy Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chacko","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Medicine at St. Vincent's Hospital St. Vincent's Institute of Medical Research University of Melbourne Fitzroy Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise E.","family":"Purton","sequence":"additional","affiliation":[{"name":"Department of Medicine at St. Vincent's Hospital St. Vincent's Institute of Medical Research University of Melbourne Fitzroy Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl R.","family":"Walkley","sequence":"additional","affiliation":[{"name":"Department of Medicine at St. Vincent's Hospital St. Vincent's Institute of Medical Research University of Melbourne Fitzroy Vic. 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