{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:58:10Z","timestamp":1790233090644,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with systemic mastocytosis have an increased risk of osteoporosis, however, the risk of osteoporotic fractures among the classic chronic myeloproliferative neoplasms (<jats:styled-content style=\"fixed-case\">CMPN<\/jats:styled-content>), including essential thrombocythaemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>), polycythaemia vera (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) and chronic myeloid leukaemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>), is unknown. We conducted a population\u2010based cohort study to determine the risk of osteoporotic fractures among three cohorts of patients with newly diagnosed <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PV<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>. Patients were identified in medical registers including all <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anish hospitals during 1980\u20132010 and were followed until first osteoporotic fracture. Fracture risk was compared to cohorts from the general population matched on age, sex and calendar year. We followed 7595 <jats:styled-content style=\"fixed-case\">CMPN<\/jats:styled-content> patients and 338\u00a0974 comparison cohort members. We found that the risk of femoral fracture after 5\u00a0years was consistently higher than the general population, being 3\u00b701% (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 2\u00b720\u20134\u00b710), 4\u00b774% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 4\u00b706\u20135\u00b752) and 4\u00b764% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3\u00b729\u20136\u00b753) among <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PV<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients respectively. Adjusted hazard ratio for femoral fracture was increased 1\u00b719\u2010fold (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b794\u20131\u00b751) for <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients, 1\u00b782\u2010fold (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b762\u20132\u00b704) for <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> patients, and 2\u00b767\u2010fold (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b797\u20133\u00b762) for <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients. We conclude that <jats:styled-content style=\"fixed-case\">CMPN<\/jats:styled-content> patients are at higher risk of osteoporotic fractures than the general population.<\/jats:p>","DOI":"10.1111\/bjh.12581","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:30:02Z","timestamp":1381541402000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Chronic myeloproliferative neoplasms and risk of osteoporotic fractures; a nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"163","author":[{"given":"Sarah","family":"Farmer","sequence":"first","affiliation":[{"name":"Department of Haematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzs\u00e9bet","family":"Horv\u00e1th\u2010Puh\u00f3","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Pernille","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.5298"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.124511"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051140"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7146"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070075"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348755"},{"key":"e_1_2_8_9_1","first-page":"281","article-title":"Bone mastocytosis. A report of nine cases with a bone histomorphometric study","volume":"279","author":"Gennes C.","year":"1992","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-394775"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.38"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.1925"},{"key":"e_1_2_8_13_1","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe E.S.","year":"2001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1686-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23155"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11831"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.9.898"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-078097"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200506000-00002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-010-9429-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.760734"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23134"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39050.597350.47"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23135"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02780.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00663015"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.12581","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.12581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:02:54Z","timestamp":1696305774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.12581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,30]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/bjh.12581"],"URL":"https:\/\/doi.org\/10.1111\/bjh.12581","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,30]]},"assertion":[{"value":"2013-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}