{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:09Z","timestamp":1791346629681,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Very few studies have investigated the effects of exercise on the biological parameters involved in vaso\u2010occlusive events in sickle cell anaemia (\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    ). The aim of this study was to test how a mild\u2010moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    patients and healthy individuals. Eleven patients with\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    and 15 healthy subjects completed a 20\u2010min duration submaximal cycling exercise at \u224845\u00a0Watts. Plasma markers of oxidative stress, antioxidant activity, endothelial activation and nitric oxide bioavailability were investigated before and after the exercise. Nitric oxide levels, anti\u2010oxidant capacity, soluble (s)E\u2010selectin and\n                    <jats:styled-content style=\"fixed-case\">sP<\/jats:styled-content>\n                    \u2010selectin did not change in response to this exercise. Except for the malondialdehyde levels, which increased in the two groups, the other markers of oxidative stress remained unchanged in both groups in response to exercise. Soluble vascular cell adhesion molecule 1 levels were increased at the end of exercise in both groups.\n                    <jats:styled-content style=\"fixed-case\">sL<\/jats:styled-content>\n                    \u2010selectin decreased and soluble intercellular adhesion molecule 1 increased with exercise in\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    patients only. The present data suggest that patients with\n                    <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>\n                    may undertake mild\u2010moderate physical activities without any acute clinical complications, but care should be taken because oxidative stress and endothelial activation significantly increased in some patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.12594","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T02:27:27Z","timestamp":1386210447000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation"],"prefix":"10.1111","volume":"164","author":[{"given":"Camille","family":"Faes","sequence":"first","affiliation":[{"name":"CRIS EA647 Universit\u00e9 de Lyon 1 Villeurbanne 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