{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:04:35Z","timestamp":1791752675592,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T00:00:00Z","timestamp":1383609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Past reports have suggested that antiphospholipid (a<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>) antibodies may emerge as a response to antipsychotics treatment, as a high prevalence of a<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> antibodies in antipsychotics users has been observed. However, no control group of non\u2010medicated psychiatric patients was included in these reports. In a cross sectional study we determined the prevalence of a<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> antibodies in 333 psychiatric inpatients. We compared the proportions of positive a<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> antibodytests between users and non\u2010users of antipsychotics with adjustments for potential confounders. The proportion of antipsychotics users carrying at least one a<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> antibody ranged from 10\u00b78% to 27\u00b70% compared with 6\u00b78% to 27\u00b72% in non\u2010users (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b724, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b724) depending on the method of detection of lupus anticoagulant (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>). The prevalence of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> detected by dilute Russell viper venom time or partial thromboplastin time\u2010<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> was not different between antipsychotics users and non\u2010users (8\u00b71% vs. 5\u00b74%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b753 and 18\u00b74% vs. 18\u00b72%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b722), as well as the prevalence of Ig<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> and Ig<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> anti\u2010\u03b22\u2010glycoprotein\u2010I antibodies, Ig<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> and Ig<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> anti\u2010cardiolipin antibodies(3\u00b78% vs. 2\u00b70%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b775, 0\u00b70% vs. 0\u00b70%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a0not applicable, 1\u00b71 vs. 1\u00b74%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b791, 2\u00b77% vs. 3\u00b74%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b771). In conclusion, a<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> antibodies were frequently found in patients with psychiatric diseases and no significant increase in the prevalence of a<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> antibodies was observed in antipsychotics users.<\/jats:p>","DOI":"10.1111\/bjh.12627","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T08:56:45Z","timestamp":1383641805000},"page":"272-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence of antiphospholipid antibodies in psychiatric patients users and non\u2010users of antipsychotics"],"prefix":"10.1111","volume":"164","author":[{"given":"Aur\u00e9lien","family":"Delluc","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bretagne Occidentale, EA 3878 (GETBO) Brest France"},{"name":"D\u00e9partement de M\u00e9decine Interne et Pneumologie CHRU Brest Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Rousseau","sequence":"additional","affiliation":[{"name":"DiagnosticaStago PAE Parispace Gennevilliers Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Le Galudec","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bretagne Occidentale, EA 3878 (GETBO) Brest France"},{"name":"CHRU de Brest Secteur hospitalo\u2010univeristaire de Psychiatrie d'adultes Bohars France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Canceil","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Paris Descartes Universit\u00e9 Paris Descartes Service Hospitalo\u2010universitaire Centre Hospitalier Sainte\u2010Anne Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Woodhams","sequence":"additional","affiliation":[{"name":"DiagnosticaStago PAE Parispace Gennevilliers Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Etienne","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Paris Descartes Universit\u00e9 Paris Descartes Service Hospitalo\u2010universitaire Centre Hospitalier Sainte\u2010Anne Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Walter","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bretagne Occidentale, EA 3878 (GETBO) Brest France"},{"name":"CHRU de Brest P\u00f4le de Psychiatrie Bohars France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Mottier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bretagne Occidentale, EA 3878 (GETBO) Brest 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