{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:07:55Z","timestamp":1760267275378},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T00:00:00Z","timestamp":1382745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The Tokyo Children's Cancer Study Group conducted a randomized controlled study to evaluate the effect of experimental early intensification using high\u2010dose cytarabine and L\u2010asparaginase in paediatric intermediate\u2010risk (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>). A total of 310 <jats:styled-content style=\"fixed-case\">IR ALL<\/jats:styled-content> patients were randomized to receive either experimental early intensification (<jats:italic>n<\/jats:italic>\u00a0=\u00a0156) or standard early intensification including standard\u2010dose cytarabine arm (<jats:italic>n<\/jats:italic>\u00a0=\u00a0154) after induction therapy. The experimental arm consisted of high\u2010dose cytarabine and L\u2010asparaginase, while the standard arm consisted of standard\u2010dose cytarabine, oral 6\u2010mercaptopurine and cyclophosphamide. The probabilities of event\u2010free survival at 8\u00a0years in the experimental and standard arms were 72\u00b73\u00a0\u00b1\u00a03\u00b77% and 77\u00b75\u00a0\u00b1\u00a03\u00b75%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b732). The 8\u2010year overall survival rates for these two arms were 85\u00b70\u00a0\u00b1\u00a03\u00b70% and 86\u00b79\u00a0\u00b1\u00a02\u00b78%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b772). The frequency of infectious events was significantly higher in the experimental arm (66\u00b74%) than in the standard arm (24\u00b76%) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). In conclusion, experimental early intensification including high\u2010dose cytarabine followed by L\u2010asparaginase had no advantage over standard early intensification in paediatric <jats:styled-content style=\"fixed-case\">IR ALL<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/bjh.12632","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T08:17:20Z","timestamp":1382775440000},"page":"376-383","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["No impact of high\u2010dose cytarabine and asparaginase as early intensification with intermediate\u2010risk paediatric acute lymphoblastic leukaemia: results of randomized trial <scp>TCCSG<\/scp> study L99\u201015"],"prefix":"10.1111","volume":"164","author":[{"given":"Motohiro","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Haematology\/Oncology Saitama Children's Medical Centre Saitama 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