{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:25:19Z","timestamp":1792337119874,"version":"4.4.0"},"reference-count":97,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T00:00:00Z","timestamp":1388188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    That primaquine and other drugs can trigger acute haemolytic anaemia in subjects who have an inherited mutation of the glucose 6\u2010phosphate dehydrogenase (G6\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    ) gene has been known for over half a century: however, these events still occur, because when giving the drug either the G6\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    status of a person is not known, or the risk of this potentially life\u2010threatening complication is under\u2010estimated. Here we review briefly the genetic basis of G6\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    deficiency, and then the pathophysiology and the clinical features of drug\u2010induced haemolysis; we also update the list of potentially haemolytic drugs (which includes rasburicase). It is now clear that it is not good practice to give one of these drugs before testing a person for his\/her G6\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    status, especially in populations in whom G6\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    deficiency is common. We discuss therefore how G6\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    testing can be done reconciling safety with cost; this is once again becoming of public health importance, as more countries are moving along the pathway of malaria elimination, that might require mass administration of primaquine. Finally, we sketch the triangular relationship between malaria, antimalarials such as primaquine, and G6\n                    <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                    deficiency: which is to some extent protective against malaria, but also a genetically determined hazard when taking primaquine.\n                  <\/jats:p>","DOI":"10.1111\/bjh.12665","type":"journal-article","created":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T03:19:07Z","timestamp":1388200747000},"page":"469-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":189,"title":["G6\n                    <scp>PD<\/scp>\n                    deficiency: a classic example of pharmacogenetics with on\u2010going clinical implications"],"prefix":"10.1111","volume":"164","author":[{"given":"Lucio","family":"Luzzatto","sequence":"first","affiliation":[{"name":"Istituto Toscano Tumori and Department of Haematology University of Florence Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Seneca","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Naples Federico II Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/189686a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5832.110-b"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16350-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21660"},{"key":"e_1_2_8_6_1","first-page":"151","article-title":"Post\u2010hemolytic renal failure in children with glucose\u20106\u2010phosphate dehydrogenase deficiency at the University Hospital Center in Lome","volume":"63","author":"Balaka B.","year":"2003","journal-title":"Medecine Tropicale: Revue Du Crops De Sant\u00e9 Colonial"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-011-9484-3"},{"key":"e_1_2_8_8_1","volume-title":"Biochemistry","author":"Berg J.M.","year":"2002"},{"key":"e_1_2_8_9_1","first-page":"53p","article-title":"Standardization of procedures for the study of glucose\u20106\u2010phosphate dehydrogenase","volume":"366","author":"Betke K.","year":"1967","journal-title":"World Health Organization Technical Report Series"},{"key":"e_1_2_8_10_1","first-page":"84","article-title":"The glutathione instability of drug\u2010sensitive red cells. 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