{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:27:53Z","timestamp":1782167273427,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The role of the proliferation index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>) as an outcome predictor in follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) isn't clear. We have previously demonstrated that quantitative image analysis (<jats:styled-content style=\"fixed-case\">QIA<\/jats:styled-content>) is a robust tool for <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> determination and the present study aimed to determine the significance of the <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> for outcome in low\u2010grade <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>. One hundred and twenty\u2010nine patients with grade 1\u20132 <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> were retrospectively analysed. Slides were scanned digitally and follicle\/tumour\u2010involved areas were annotated. The intrafollicular <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> was estimated by analysing a median of 10 follicles per case. Patients were divided into two groups: <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>\u00a0&lt;\u00a030%, <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>\u00a0\u2265\u00a030% and clinical outcome was analysed. Among the 129 patients analysed, intrafollicular <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> ranged from 0\u00b76 to 63\u00b72% with a median of 23\u00b73%. Overall survival was not influenced by <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> group. Among those patients initially observed, intrafollicular <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>\u00a0&lt;\u00a030% was associated with longer time to first therapy compared to patients with a <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>\u00a0\u2265\u00a030%. In the group of patients that were treated at diagnosis, <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> was not predictive of time to treatment failure (<jats:styled-content style=\"fixed-case\">TTTF<\/jats:styled-content>). Intrafollicular <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> is an important predicator of <jats:styled-content style=\"fixed-case\">TTFT<\/jats:styled-content> for patients who are candidates for observation. Further confirmation in an independent cohort of patients is necessary to determine the clinical validity of the results.<\/jats:p>","DOI":"10.1111\/bjh.12667","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T10:56:46Z","timestamp":1386241006000},"page":"646-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of quantitative assessment of the intrafollicular proliferation index with outcome in follicular lymphoma"],"prefix":"10.1111","volume":"164","author":[{"given":"Meirav","family":"Kedmi","sequence":"first","affiliation":[{"name":"Lymphoma Service Memorial Sloan\u2010Kettering Cancer Center New York NY, USA"},{"name":"Hematology Division Chaim Sheba Medical Center Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus V.","family":"Hedvat","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Maragulia","sequence":"additional","affiliation":[{"name":"Lymphoma Service Memorial Sloan\u2010Kettering Cancer Center New York NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Zelenetz","sequence":"additional","affiliation":[{"name":"Lymphoma Service Memorial Sloan\u2010Kettering Cancer Center New York NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.11.829"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14110-4"},{"key":"e_1_2_6_4_1","first-page":"6","article-title":"An intergroup randomised trial of rituximab versus a watch and wait strategy in patients with stage II, III, IV, asymptomatic, non\u2010bulky follicular lymphoma (grades 1, 2 and 3a). 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