{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:25:21Z","timestamp":1791181521473,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Summary<\/jats:title>Follicular Lymphoma (FL<\/jats:styled-content>) is the second most common non\u2010Hodgkin lymphoma (NHL<\/jats:styled-content>) subtype and its course is heterogeneous. At diagnosis, some patients with FL<\/jats:styled-content> manifest a detectable leukaemic phase (FL<\/jats:styled-content>\u2010LP<\/jats:styled-content>), but this feature has been seldom described and is poorly characterized. Among 499 patients diagnosed with FL<\/jats:styled-content> in Lyon\u2010Sud hospital, 37 (7\u00b74%) had characteristic FL<\/jats:styled-content>\u2010LP<\/jats:styled-content> (by cytological blood smears and flow cytometric analysis). In addition, 91\/1135 FL<\/jats:styled-content> patients from the PRIMA<\/jats:styled-content> study presented FL<\/jats:styled-content>\u2010LP<\/jats:styled-content> at study entry. In order to evaluate the outcome of this Lyon\u2010Sud cohort, FL<\/jats:styled-content>\u2010LP<\/jats:styled-content> patients were matched with 111 newly diagnosed FL<\/jats:styled-content> without LP<\/jats:styled-content> according to the Follicular Lymphoma International Prognostic Index (FLIPI<\/jats:styled-content>) score, age and treatment. Presence of FL<\/jats:styled-content>\u2010LP<\/jats:styled-content> was associated with shorter progression\u2010free survival (PFS<\/jats:styled-content>) and overall survival (OS<\/jats:styled-content>) (P<\/jats:italic>\u00a0=\u00a00\u00b7004 and P<\/jats:italic>\u00a0=\u00a00\u00b7031, respectively). Presence of FL<\/jats:styled-content>\u2010LP<\/jats:styled-content> and high FLIPI<\/jats:styled-content> score remained independent prognostic factors in a Cox model for time to progression (TTP<\/jats:styled-content>). A number of circulating lymphoma cells (CLC<\/jats:styled-content>) >4\u00a0\u00d7\u00a0109<\/jats:sup>\/l was the most significant predictor for a shorter TTP<\/jats:styled-content> in this Cox model. The prognostic impact of FL<\/jats:styled-content>\u2010LP<\/jats:styled-content> on TTP<\/jats:styled-content> was validated in the PRIMA<\/jats:styled-content> cohort (P<\/jats:italic>\u00a0=\u00a00\u00b70004). In conclusion, FL<\/jats:styled-content>\u2010LP<\/jats:styled-content> is a rare event associated with shorter PFS<\/jats:styled-content> and patients with CLC<\/jats:styled-content> >4\u00a0\u00d7\u00a0109<\/jats:sup>\/l have a poorer outcome. These patients should be monitored carefully to consider alternative therapeutic options.<\/jats:p>","DOI":"10.1111\/bjh.12675","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T09:39:29Z","timestamp":1385458769000},"page":"659-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Peripheral blood involvement in patients with follicular lymphoma: a rare disease manifestation associated with poor prognosis"],"prefix":"10.1111","volume":"164","author":[{"given":"Cl\u00e9mentine","family":"Sarkozy","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon (HCL) Service d'H\u00e9matologie Centre Hospitalier Lyon Sud (CHLS) Pierre Benite Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Baseggio","sequence":"additional","affiliation":[{"name":"HCL Service d'h\u00e9matologie biologique CHLS Pierre Benite Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Feugier","sequence":"additional","affiliation":[{"name":"CHU de Nancy Universit\u00e9 de Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Callet\u2010Bauchu","sequence":"additional","affiliation":[{"name":"HCL Service d'h\u00e9matologie biologique unit\u00e9 de cytog\u00e9n\u00e9tique CHLS Pierre Benite Cedex France"},{"name":"Universit\u00e9 Lyon1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Karlin","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon (HCL) Service d'H\u00e9matologie Centre Hospitalier Lyon Sud (CHLS) Pierre Benite Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Seymour","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre and University of Melbourne Melbourne Vic. 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