{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:32:58Z","timestamp":1771882378447,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The use of highly effective rituximab\u2010containing therapy for treating diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) makes it more difficult to salvage relapsed or refractory patients. Autologous stem\u2010cell transplantation (<jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>) is the reference treatment for these patients, but the impact of previous exposure to rituximab on the subsequent results of <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content> remains unknown. We analysed 248 patients with relapsed or refractory <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> or grade 3B follicular lymphoma pre\u2010treated with rituximab as part of first\u2010line therapy (R+ group) who received <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>, in comparison with a control group of 127 patients without previous exposure to rituximab (R\u2212 group). The complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) rates were similar in both groups. Multivariate analysis identified age\u2010adjusted International Prognostic Index at diagnosis, extranodal involvement and disease status at transplant, and the number of previous chemotherapy lines as independent factors with a negative influence on <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> rate. Compared with R\u2212 patients, those in the R+ group had a significantly better progression\u2010free survival (63% vs. 48% at 5\u00a0years) and overall survival (72% vs. 61% at 5\u00a0years). This observation was independent of other prognostic factors that affected these outcomes. In conclusion, <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content> is no less effective in patients with relapsed or refractory aggressive B\u2010cell lymphoma pre\u2010treated with first\u2010line rituximab\u2010containing therapy than in rituximab\u2010naive patients.<\/jats:p>","DOI":"10.1111\/bjh.12676","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T09:39:45Z","timestamp":1385458785000},"page":"668-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of prior rituximab on outcomes of autologous stem\u2010cell transplantation in patients with relapsed or refractory aggressive B\u2010cell lymphoma: a multicentre retrospective Spanish group of lymphoma\/autologous bone marrow transplant study"],"prefix":"10.1111","volume":"164","author":[{"given":"Alba M.","family":"Redondo","sequence":"first","affiliation":[{"name":"Hospital Universitario de 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