{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:40:42Z","timestamp":1791351642598,"version":"4.3.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Summary<\/jats:title>\n \n To evaluate the association between haemoglobinuria and chronic kidney disease (\n CKD<\/jats:styled-content>\n ) in sickle cell anaemia (\n SCA<\/jats:styled-content>\n ), we analysed 356 adult haemoglobin\n SS<\/jats:styled-content>\n or S\u03b2\n o<\/jats:sup>\n thalassaemia patients from the University of Illinois at Chicago (\n UIC<\/jats:styled-content>\n ) and 439 from the multi\u2010centre Walk\u2010Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy (Walk\u2010\n PH<\/jats:styled-content>\n a\n SST<\/jats:styled-content>\n ) cohort.\n CKD<\/jats:styled-content>\n was classified according to National Kidney Foundation Kidney Disease Outcomes Quality Initiatives guidelines. Haemoglobinuria, defined as positive haem on urine dipstick with absent red blood cells on microscopy, was confirmed by enzyme\u2010linked immunosorbent assay in a subset of patients. The prevalence of\n CKD<\/jats:styled-content>\n was 58% in the\n UIC<\/jats:styled-content>\n cohort and 54% in the Walk\u2010\n PH<\/jats:styled-content>\n a\n SST<\/jats:styled-content>\n cohort, and haemoglobinuria was observed in 36% and 20% of the patients, respectively. Pathway analysis in both cohorts indicated an independent association of lactate dehydrogenase with haemoglobinuria and, in turn, independent associations of haemoglobinuria and age with\n CKD<\/jats:styled-content>\n (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0\u00b70001). After a median of 32\u00a0months of follow\u2010up in the\n UIC<\/jats:styled-content>\n cohort, haemoglobinuria was associated with progression of\n CKD<\/jats:styled-content>\n [halving of estimated glomerular filtration rate or requirement for dialysis; Hazard ratio (\n HR<\/jats:styled-content>\n ) 13\u00b79, 95% confidence interval (\n CI<\/jats:styled-content>\n ) 1\u00b77\u2013113\u00b72,\n P\u00a0=\u00a0<\/jats:italic>\n 0\u00b70012] and increasing albuminuria (\n HR<\/jats:styled-content>\n 3\u00b71, 95%\n CI<\/jats:styled-content>\n : 1\u00b73\u20137\u00b77; logrank\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0\u00b70035). In conclusion haemoglobinuria is common in\n SCA<\/jats:styled-content>\n and is associated with\n CKD<\/jats:styled-content>\n , consistent with a role for intravascular haemolysis in the pathogenesis of renal dysfunction in\n SCA<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/bjh.12690","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T04:29:07Z","timestamp":1386822547000},"page":"729-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia"],"prefix":"10.1111","volume":"164","author":[{"given":"Santosh L.","family":"Saraf","sequence":"first","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamir","family":"Kanias","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine Vascular Medicine Institute University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Lash","sequence":"additional","affiliation":[{"name":"Section of Nephrology Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Molokie","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"},{"name":"Jesse Brown VA Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharvi","family":"Oza","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lai","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie H.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Gowhari","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johara","family":"Hassan","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"DeSimone","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto F.","family":"Machado","sequence":"additional","affiliation":[{"name":"Section of Pulmonary\/Critical Care Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Gladwin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine Vascular Medicine Institute University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Little","sequence":"additional","affiliation":[{"name":"Section of Hematology and Oncology Case Western Reserve University Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Medicine Comprehensive Sickle Cell Center University of Illinois at Chicago Chicago IL 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