{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:53:00Z","timestamp":1773827580818,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Karl-Thiemig-Stiftung"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Extranodal marginal zone lymphoma of mucosa\u2010associated lymphoid tissue (<jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma) comprises 7\u20138% of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphomas and commonly originates from a background of long\u2010standing chronic inflammation. An association with distinct bacteria species has been confirmed for several anatomical sites of <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma. For pulmonary <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma, however, a clear link with an infectious agent or autoimmune disorder has not yet been reported. Using a 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> gene\u2013based approach, we have recently identified <jats:italic>Achromobacter (Alcaligenes) xylosoxidans<\/jats:italic> in eight of nine cases of pulmonary <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma. <jats:italic>A.\u00a0xylosoxidans<\/jats:italic> is a gram\u2010negative betaproteobacterium with low virulence, but high resistance to antibiotic treatment. To further examine a potential association with <jats:italic>A.\u00a0xylosoxidans,<\/jats:italic> 124 cases of pulmonary <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma and 82 control tissues from six European countries were analysed using a specific nested <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Although prevalence rates for <jats:italic>A.\u00a0xylosoxidans<\/jats:italic> varied significantly from country to country, they were consistently higher for <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma as compared to controls. Overall, 57\/124 (46%) pulmonary <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphomas and 15\/82 (18%) control tissues were positive for <jats:italic>A.\u00a0xylosoxidans<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004). Whether the significant association of <jats:italic>A.\u00a0xylosoxidans<\/jats:italic> with pulmonary <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma demonstrated in our study points to a potential causal role in the pathogenesis of this lymphoma will require further studies.<\/jats:p>","DOI":"10.1111\/bjh.12703","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T11:29:01Z","timestamp":1387798141000},"page":"804-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Prevalence of <i><scp>A<\/scp>chromobacter xylosoxidans<\/i> in pulmonary mucosa\u2010associated lymphoid tissue lymphoma in different regions of <scp>E<\/scp>urope"],"prefix":"10.1111","volume":"164","author":[{"given":"Patrick","family":"Adam","sequence":"first","affiliation":[{"name":"Institute of Pathology University of T\u00fcbingen T\u00fcbingen 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