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They are defined by microangiopathic haemolytic anaemia and thrombocytopenia, with renal involvement primarily in a<jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content> and neurological and cardiological sequelae in <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>. Prompt treatment for most cases of both conditions is with plasma exchange initially and monoclonal therapy (rituximab in <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> and eculizumab in a<jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>) as the mainstay of therapy. Here we discuss the diagnosis and therapy for both disorders.<\/jats:p>","DOI":"10.1111\/bjh.12718","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T09:31:20Z","timestamp":1389000680000},"page":"759-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome"],"prefix":"10.1111","volume":"164","author":[{"given":"Marie","family":"Scully","sequence":"first","affiliation":[{"name":"Department of Haematology University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Goodship","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Institute of Genetic Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20166"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00050505"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06384.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06819.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10204"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010208"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-0848"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31822e9d66"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0809959"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0522"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08636.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061648"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.5858\/2003-127-834-TTPAHU","article-title":"Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. 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